Senna and Remodulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Senna (senna) and Remodulin (treprostinil sodium). Common drug interactions include dizziness among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Senna and Remodulin. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Remodulin?

Remodulin has active ingredients of treprostinil sodium. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,843 Remodulin users. Check the latest studies of Remodulin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

78 people who take Senna and Remodulin together, and have interactions are studied.

What are the common drug interactions of Senna and Remodulin, by gender? *:

female:

Dizziness
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Respiratory rate increased (excess breathing rate/min)
Oedema (fluid collection in tissue)
Renal failure (kidney dysfunction)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Hypoxia (low oxygen in tissues)
Oesophageal achalasia (difficulty swallowing, food sticking in the oesophagus)
Abdominal distension

male:

Nausea (feeling of having an urge to vomit)
Vomiting
Injection site infection
Injection site pain
Injection site swelling
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Abdominal pain

What are the common drug interactions of Senna and Remodulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Oxygen saturation decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory rate increased (excess breathing rate/min)
Cardiac arrest
Hyperkalaemia (damage to or disease of the kidney)
Respiratory distress (difficulty in breathing)
Respiratory tract infection
Tracheitis (an inflammation of the trachea)
Device dislocation

10-19:

Abdominal pain
Faecaloma (hard mass of fecal matter)

20-29:

Colitis ulcerative (inflammation of colon with ulcer)
Hypervolaemia (abnormally increased volume of blood)
Transplant

30-39:

Arthralgia (joint pain)
Cough
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Oedema peripheral (superficial swelling)
Pain in extremity
Thrombosis (formation of a blood clot inside a blood vessel)

40-49:

Hypotension (abnormally low blood pressure)
Pain
Oesophageal achalasia (difficulty swallowing, food sticking in the oesophagus)
Dyspnoea (difficult or laboured respiration)
Abdominal pain
Chest pain
Cough
Fatigue (feeling of tiredness)
Headache (pain in head)
Oedema peripheral (superficial swelling)

50-59:

Staphylococcal infection (an infection with staphylococcus bacteria)
Vomiting
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Blood creatinine decreased
Blood pressure decreased
Cough
Cystitis (inflammation of the wall of the bladder)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Interstitial lung disease
Pulmonary hypertension (increase in blood pressure in the lung artery)

60+:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Cardiac failure
Cardiac failure congestive
Chest pain
Fall
Headache (pain in head)
Hypertension (high blood pressure)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 10 people, 12.82%
Stress And Anxiety: 9 people, 11.54%
Insomnia (sleeplessness): 7 people, 8.97%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 7.69%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 5 people, 6.41%
Pain In Extremity: 5 people, 6.41%
Pain: 5 people, 6.41%
Nausea And Vomiting: 4 people, 5.13%
Nausea (feeling of having an urge to vomit): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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