Septra ds and Doxycycline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Septra ds (sulfamethoxazole; trimethoprim) and Doxycycline (doxycycline hyclate). Common drug interactions include migraine among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Septra ds and Doxycycline. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Septra ds?

Septra ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 2,349 Septra ds users. Check the latest studies of Septra ds.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

On Jul, 07, 2026

50 people who take Septra ds and Doxycycline together, and have interactions are studied.

Septra ds and Doxycycline drug interactions.

What are the common drug interactions of Septra Ds and Doxycycline, by gender? *:

female:

Migraine (headache)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Abdominal pain lower
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Asthenia (weakness)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coma (state of unconsciousness lasting more than six hours)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pneumonia
Cardiac disorder
Chest pain
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Groin pain
Ileitis (inflammation of the ileum)
Inflammatory bowel disease

What are the common drug interactions of Septra Ds and Doxycycline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anal fistula
Aspartate aminotransferase increased
Asthenia (weakness)
Atherosclerosis (disorder of the arteries)
Blood cholesterol increased
Blood triglycerides increased
Bone pain
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

30-39:

Hypertension (high blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)
Nerve compression
Hypoaesthesia (reduced sense of touch or sensation)
Myalgia (muscle pain)
Tendon pain

40-49:

Aphasia (damage to the parts of the brain that control language)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dysarthria (speech disorder)
Headache (pain in head)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Migraine (headache)

50-59:

Cholangitis (infection of the bile duct)
Erythema (redness of the skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

60+:

Ear pain
Arthralgia (joint pain)
Pyrexia (fever)
Sputum increased
Vitamin a deficiency
Wheezing (a high-pitched whistling sound made while you breath)
Pneumonia
Fall
Influenza like illness
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 24.00%
Cough: 12 people, 24.00%
Infective Pulmonary Exacerbation Of Cystic Fibrosis (severe infective lung disease with production of abnormally thick mucus): 11 people, 22.00%
Dyspnea (difficult or laboured breathing): 11 people, 22.00%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 11 people, 22.00%
Joint Pain: 10 people, 20.00%
Sputum Increased: 10 people, 20.00%
Sinusitis (inflammation of sinus): 10 people, 20.00%
High Blood Pressure: 9 people, 18.00%
Cystic Fibrosis (disease of the secretary glands): 9 people, 18.00%

* Approximation only. Some reports may have incomplete information.

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