Septra and Gliclazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Septra (sulfamethoxazole; trimethoprim) and Gliclazide (gliclazide). Common drug interactions include oedema among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Septra and Gliclazide. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

What is Gliclazide?

Gliclazide has active ingredients of gliclazide. It is often used in diabetes. eHealthMe is studying from 28,131 Gliclazide users. Check the latest studies of Gliclazide.

On Aug, 04, 2026

64 people who take Septra and Gliclazide together, and have interactions are studied.

Septra and Gliclazide drug interactions.

What are the common drug interactions of Septra and Gliclazide, by gender? *:

female:

Oedema (fluid collection in tissue)
Oxygen saturation decreased
Protein total increased
Proteinuria (presence of protein in the urine)
Red blood cell count increased
Red cell distribution width increased
Renal impairment (severely reduced kidney function)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Vasculitis (inflammation of a blood vessel or blood vessels)

male:

Asthenia (weakness)
Pneumonia
Vomiting
Acute respiratory distress syndrome
Bacteraemia (presence of bacteria in the blood)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Dysphagia (a condition in which swallowing is difficult or painful)
Febrile neutropenia (fever with reduced white blood cells)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Lung disorder (lung disease)

What are the common drug interactions of Septra and Gliclazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Infusion related reaction
Back pain
Blood glucose increased
Blood pressure fluctuation
Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Lower respiratory tract infection

30-39:

n/a

40-49:

Blood pressure increased
Hypotension (abnormally low blood pressure)
Oral pruritus (itching in mouth)
Skin ulcer
Weight decreased
Arthralgia (joint pain)
Blood pressure fluctuation
Bone loss
Calcinosis (calcium deposits in any soft tissue)
Infusion related reaction

50-59:

Fall
Furuncle (infection of the hair follicle)
Gastrointestinal arteriovenous malformation (malformation of arteries and veins in gastrointestinal tract)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Infusion related reaction
Iron deficiency anaemia
Melaena (the passage of black, tarry stools)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Respiratory failure (inadequate gas exchange by the respiratory system)
Acute respiratory distress syndrome
Arthralgia (joint pain)
Bacteraemia (presence of bacteria in the blood)
Blood albumin decreased
Blood creatinine increased
Blood glucose increased
Blood osmolarity decreased

What are the existing conditions these people have? *

Vasculitis (inflammation of a blood vessel or blood vessels): 12 people, 18.75%
High Blood Pressure: 9 people, 14.06%
Pneumonia: 8 people, 12.50%
Oral Candidiasis (fungal infection of mouth): 6 people, 9.38%
Nasopharyngeal Cancer (cancer of nasopharynx): 5 people, 7.81%
High Blood Cholesterol: 5 people, 7.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.81%
Back Pain: 5 people, 7.81%
Pain In Extremity: 4 people, 6.25%
Microscopic Polyangiitis (inflammation involving multiple blood or lymph small-vessel): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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