Septra and Ketoconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Septra (sulfamethoxazole; trimethoprim) and Ketoconazole (ketoconazole). Common drug interactions include haemoptysis among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Septra and Ketoconazole. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

On Jul, 10, 2026

69 people who take Septra and Ketoconazole together, and have interactions are studied.

Septra and Ketoconazole drug interactions.

What are the common drug interactions of Septra and Ketoconazole, by gender? *:

female:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Lower respiratory tract infection
Pancreatitis acute (sudden inflammation of pancreas)
Respiratory failure (inadequate gas exchange by the respiratory system)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Anaemia (lack of blood)
Chronic kidney disease
Cough
Fatigue (feeling of tiredness)

male:

Anaemia (lack of blood)
Bone disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gingival pain (gum pain)
Gingivitis (inflammation of gums)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Biliary cyst
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Blood testosterone decreased

What are the common drug interactions of Septra and Ketoconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood creatinine increased
Leukopenia (less number of white blood cells in blood)

30-39:

Chest tightness
Dyspnoea (difficult or laboured respiration)
Mitral valve incompetence (inefficient heart valve)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Right ventricular failure (right half of the heart fails to work)

40-49:

Anaemia (lack of blood)
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Biliary cyst
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Blood testosterone decreased
Blood urine present
Bone disorder
Bone pain

50-59:

Lower respiratory tract infection
Pancreatitis acute (sudden inflammation of pancreas)
Chills (felling of cold)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cough

60+:

Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Actinic elastosis (disorder in which the skin appears yellow and thickened as a result of sun damage)
Actinic keratosis (skin disease due to sun exposure)
Adjustment disorder with mixed anxiety and depressed mood
Anxiety disorder
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Arthralgia (joint pain)

What are the existing conditions these people have? *

High Blood Cholesterol: 20 people, 28.99%
High Blood Pressure: 19 people, 27.54%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 17.39%
Hiv Infection: 11 people, 15.94%
Diarrhea: 11 people, 15.94%
Seasonal Allergy (allergic condition due to certain season): 11 people, 15.94%
Blood Triglycerides Decreased: 11 people, 15.94%
Multiple Myeloma (cancer of the plasma cells): 11 people, 15.94%
Mood Swings (an extreme or rapid change in mood): 11 people, 15.94%
Joint Pain: 11 people, 15.94%

* Approximation only. Some reports may have incomplete information.

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