Macrodantin and Septra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Septra (sulfamethoxazole; trimethoprim). Common drug interactions include confusional state among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Septra. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

On Apr, 23, 2026

25 people who take Macrodantin and Septra together, and have interactions are studied.

Macrodantin and Septra drug interactions.

What are the common drug interactions of Macrodantin and Septra, by gender? *:

female:

Confusional state
Conjunctivitis (pink eye)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery thrombosis (clot formation in coronary artery)
Cough
Cystitis glandularis (forming a timorous lesion with blueberry spots in the urinary bladder)
Deafness
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug hypersensitivity

male:

Abdominal distension
Back pain
Nephropathy toxic (damage to kidney due to toxins)
Obstructive uropathy (a blockage that prevents urine from leaving your kidneys)
Oedema (fluid collection in tissue)
Pleural effusion (water on the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Subclavian artery thrombosis (a condition in which the blood flow through the vessel is obstructed)
Ureteric dilatation
Ureteric obstruction

What are the common drug interactions of Macrodantin and Septra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain lower
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Depression
Dysmenorrhoea (painful menstruation)
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Haemoperitoneum (presence of blood in the peritoneal cavity)
Impaired healing
Menstruation irregular
Migraine (headache)
Nausea (feeling of having an urge to vomit)

30-39:

n/a

40-49:

Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Haematuria (presence of blood in urine)
Headache (pain in head)
Heart rate increased
Herpes zoster
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

50-59:

Drug hypersensitivity
Pruritus (severe itching of the skin)

60+:

Abdominal discomfort
Arrhythmia (irregular heartbeat)
Weight decreased
Asthenia (weakness)
International normalised ratio increased
Anaemia (lack of blood)
Atrophy (wasting away of a part of the body)
Haematuria (presence of blood in urine)
Activated partial thromboplastin time prolonged
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 24.00%

* Approximation only. Some reports may have incomplete information.

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