Septra and Velcade drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Septra (sulfamethoxazole; trimethoprim) and Velcade (bortezomib). Common drug interactions include sensory disturbance among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Septra and Velcade. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

What is Velcade?

Velcade has active ingredients of bortezomib. It is often used in multiple myeloma. eHealthMe is studying from 66,422 Velcade users. Check the latest studies of Velcade.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

68 people who take Septra and Velcade together, and have interactions are studied.

What are the common drug interactions of Septra and Velcade, by gender? *:

female:

Sensory disturbance (sense disturbance)
Anxiety
Blood calcium decreased
Blood creatinine increased
Blood product transfusion dependent
Blood urea increased
Chills (felling of cold)
Confusional state
Diarrhoea
Dyspnoea (difficult or laboured respiration)

male:

Pyrexia (fever)
Neuropathy peripheral (surface nerve damage)
Platelet count decreased
Thrombocythaemia (an increased number of platelets in the circulating blood)
Vomiting
Cataract (clouding of the lens inside the eye)
Dyspnoea (difficult or laboured respiration)
Groin pain
Oedema peripheral (superficial swelling)
Rash

What are the common drug interactions of Septra and Velcade, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Disease progression
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Tracheitis (an inflammation of the trachea)

10-19:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

20-29:

Herpes zoster
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Platelet count decreased
Pyrexia (fever)

30-39:

n/a

40-49:

Anaemia (lack of blood)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Spinal cord compression
Thrombocytopenia (decrease of platelets in blood)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Blood creatinine increased
Blood urea increased
Chills (felling of cold)
Confusional state

50-59:

Abdominal distension
Bone marrow failure
Dehydration (dryness resulting from the removal of water)
Electrolyte imbalance
Heart rate increased
Hypotension (abnormally low blood pressure)
Malignant neoplasm progression (cancer tumour came back)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Pyrexia (fever)
Vomiting

60+:

Neuropathy peripheral (surface nerve damage)
Epistaxis (bleed from the nose)
Asthenia (weakness)
Hypotension (abnormally low blood pressure)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Thrombocythaemia (an increased number of platelets in the circulating blood)
White blood cell count decreased
Cataract (clouding of the lens inside the eye)
Groin pain

What are the existing conditions these people have? *

Pain: 9 people, 13.24%
High Blood Pressure: 6 people, 8.82%
Haematopoietic Stem Cell Mobilisation: 6 people, 8.82%
Nausea (feeling of having an urge to vomit): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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