Serevent and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serevent (salmeterol xinafoate) and Opsumit (macitentan). Common drug interactions include cardiac failure congestive among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Serevent and Opsumit. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Serevent?

Serevent has active ingredients of salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 15,586 Serevent users. Check the latest studies of Serevent.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Jul, 04, 2026

11 people who take Serevent and Opsumit together, and have interactions are studied.

What are the common drug interactions of Serevent and Opsumit, by gender? *:

female:

Cardiac failure congestive
Dysstasia (difficulty in standing)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lung disorder (lung disease)
Myalgia (muscle pain)
Nasopharyngitis (inflammation of the nasopharynx)
Obesity (having too much body fat)

male:

Acute respiratory failure
Cardiac failure
Death
Hospitalisation
Hypoxia (low oxygen in tissues)
Pneumonia

What are the common drug interactions of Serevent and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dizziness

50-59:

n/a

60+:

Oxygen saturation decreased
Dyspnoea (difficult or laboured respiration)
Lung disorder (lung disease)
Obesity (having too much body fat)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Anxiety
Asthenia (weakness)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 54.55%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 18.18%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 9.09%
Hypersensitivity: 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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