Serevent and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Serevent (salmeterol xinafoate) and Zelnorm (tegaserod maleate). Common drug interactions include blood pressure decreased among females and abdominal adhesions among males.

The phase IV clinical study analyzes what interactions people have when they take Serevent and Zelnorm. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Serevent?

Serevent has active ingredients of salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 15,586 Serevent users. Check the latest studies of Serevent.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Jul, 12, 2026

37 people who take Serevent and Zelnorm together, and have interactions are studied.

What are the common drug interactions of Serevent and Zelnorm, by gender? *:

female:

Blood pressure decreased
Bowel sounds
Death
Diarrhoea haemorrhagic (bloody diarrhoea)
Dyspnoea (difficult or laboured respiration)
Heart rate increased
Leukocytosis (increased white blood cells)
Mucosal ulceration (ulcers of mucous membrane)
Necrosis (the death of body tissue)
Nodule (a growth of abnormal tissue)

male:

Abdominal adhesions (inflammation of abdomen)
Abdominal distension
Breast enlargement
Breast pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Cardiac disorder
Cardiovascular disorder (heart diseases)
Cerebral atrophy (decrement in size of brain)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)

What are the common drug interactions of Serevent and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective

20-29:

n/a

30-39:

Oedema peripheral (superficial swelling)
Dyspepsia (indigestion)
Erosive oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Joint swelling
Nausea (feeling of having an urge to vomit)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dizziness
Drug intolerance (drug sensitivity)
Eye discharge

40-49:

Blood prolactin increased
Galactorrhoea (secretion of breast milk in men)
International normalised ratio increased
Liver disorder (liver diseases)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Vitamin k deficiency

50-59:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Intestinal ulcer
Oedema peripheral (superficial swelling)
Pain
Acute sinusitis
Alopecia (absence of hair from areas of the body)
Arthropathy
Blood alkaline phosphatase increased
Breast mass

60+:

Abdominal pain lower
Abscess (pus)
Respiratory tract infection
Rhonchi (abnormal breath sounds)
Sputum culture positive
Staphylococcal infection (an infection with staphylococcus bacteria)
Surgery
Wheezing (a high-pitched whistling sound made while you breath)
Blood pressure decreased
Death

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 12 people, 32.43%
Constipation: 7 people, 18.92%
Pain: 6 people, 16.22%
Inflammation: 5 people, 13.51%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.81%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 8.11%
Quit Smoking: 3 people, 8.11%
Stress And Anxiety: 2 people, 5.41%
Chest Pain: 2 people, 5.41%
Cough: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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