Sertraline and Droxidopa drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Droxidopa (droxidopa). Common drug interactions include agitation among females and hallucination among males.
The phase IV clinical study analyzes what interactions people have when they take Sertraline and Droxidopa. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.
What is Sertraline?
Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.
What is Droxidopa?
Droxidopa has active ingredients of droxidopa. eHealthMe is studying from 1,093 Droxidopa users. Check the latest studies of Droxidopa.
27 people who take Sertraline and Droxidopa together, and have interactions are studied.

What are the common drug interactions of Sertraline and Droxidopa, by gender? *:
female:
- Agitation (state of anxiety or nervous excitement)
- Confusional state
- Dizziness
- Insomnia (sleeplessness)
- Mania (a state of abnormally elevated or irritable mood)
- Fatigue (feeling of tiredness)
- Death
- Restlessness (not able to rest)
- Speech disorder
- Blindness unilateral
male:
- Hallucination (an experience involving the perception of something not present)
- Drug ineffective
- Bladder disorder
- Choking sensation (feeling of obstruction in respiratory system)
- Cough
- Device occlusion
- Frequent bowel movements
- Ill-defined disorder
- Joint swelling
- Oedema peripheral (superficial swelling)
What are the common drug interactions of Sertraline and Droxidopa, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Hypokinesia (decreased bodily movement)
- Hypotension (abnormally low blood pressure)
- Loss of consciousness
60+:
- Hallucination (an experience involving the perception of something not present)
- Drug ineffective
- Death
- Insomnia (sleeplessness)
- Mania (a state of abnormally elevated or irritable mood)
- Adverse drug reaction
- Abnormal faeces (abnormal stool)
- Bladder disorder
- Choking sensation (feeling of obstruction in respiratory system)
- Cough
What are the existing conditions these people have? *
- Parkinson's Disease: 18 people, 66.67%
- Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 4 people, 14.81%
- Hallucinations (sensations that appear real but are created by your mind): 3 people, 11.11%
- Sleep Disorder: 2 people, 7.41%
- On And Off Phenomenon: 2 people, 7.41%
- Nasal Polyps (masses that develop in the lining of the nose): 2 people, 7.41%
* Approximation only. Some reports may have incomplete information.
Do you take Sertraline and Droxidopa?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Sertraline (153,305 reports)
- Droxidopa (1,093 reports)
Browse all drug interactions of Sertraline and Droxidopa:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Sertraline:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Droxidopa:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Sertraline and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Droxidopa and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on sertraline hydrochloride and droxidopa (the active ingredients of Sertraline and Droxidopa, respectively), and Sertraline and Droxidopa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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