Sertraline and Simcor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Simcor (niacin; simvastatin). Common drug interactions include flushing among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline and Simcor. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,308 Sertraline users. Check the latest studies of Sertraline.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

65 people who take Sertraline and Simcor together, and have interactions are studied.

Sertraline and Simcor drug interactions.

What are the common drug interactions of Sertraline and Simcor, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Myalgia (muscle pain)
Feeling hot
Erythema (redness of the skin)
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Fatigue (feeling of tiredness)
Skin burning sensation

male:

Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)
Sensory disturbance (sense disturbance)
Sedation
Application site dermatitis
Application site erythema (redness of the skin at application site)
Application site pain
Application site pruritus (application site severe itching of the skin)
Application site vesicles (small bubble within a cell at application site)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)

What are the common drug interactions of Sertraline and Simcor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Flushing (the warm, red condition of human skin)
Blood glucose increased
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin burning sensation
Erythema (redness of the skin)
Burning sensation
Eyelid disorder
Generalised erythema (redness of the skin all over the body)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

40-49:

Pruritus (severe itching of the skin)
Swelling face
Flushing (the warm, red condition of human skin)
Sedation
Sensation of heaviness
Sensory disturbance (sense disturbance)
Asthenia (weakness)
Chest pain
Diarrhoea
Erythema (redness of the skin)

50-59:

Feeling hot
Pruritus (severe itching of the skin)
Flushing (the warm, red condition of human skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Myalgia (muscle pain)
Arthralgia (joint pain)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)

60+:

Pruritus (severe itching of the skin)
Erythema (redness of the skin)
Abdominal discomfort
Application site dermatitis
Application site erythema (redness of the skin at application site)
Application site pain
Application site pruritus (application site severe itching of the skin)
Application site vesicles (small bubble within a cell at application site)
Burning sensation
Hot flush (sudden feelings of heat)

What are the existing conditions these people have? *

High Density Lipoprotein Decreased: 8 people, 12.31%
Low Density Lipoprotein Increased (cholesterol increased in blood): 7 people, 10.77%
High Blood Pressure: 5 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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