Sertraline and Sovaldi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sertraline (sertraline hydrochloride) and Sovaldi (sofosbuvir). Common drug interactions include headache among females and altered state of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Sertraline and Sovaldi. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,302 Sertraline users. Check the latest studies of Sertraline.

What is Sovaldi?

Sovaldi has active ingredients of sofosbuvir. eHealthMe is studying from 12,697 Sovaldi users. Check the latest studies of Sovaldi.

On Jun, 17, 2026

43 people who take Sertraline and Sovaldi together, and have interactions are studied.

Sertraline and Sovaldi drug interactions.

What are the common drug interactions of Sertraline and Sovaldi, by gender? *:

female:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Anaemia (lack of blood)
Ataxia (loss of full control of bodily movements)
Blood potassium decreased
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haematemesis (vomiting of blood)
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Altered state of consciousness (altered state of mind)
Coma hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma)
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin
Dyspnoea (difficult or laboured respiration)
Emotional distress
Faeces discoloured
Fatigue (feeling of tiredness)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

What are the common drug interactions of Sertraline and Sovaldi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Emotional distress
Pain
Renal impairment (severely reduced kidney function)

40-49:

Anaemia (lack of blood)
Death
Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dysuria (painful or difficult urination)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Pleural effusion (water on the lungs)
Pneumonia
Presyncope

50-59:

Fatigue (feeling of tiredness)
Ataxia (loss of full control of bodily movements)
Blood potassium decreased
Cellulitis (infection under the skin)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Haematemesis (vomiting of blood)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

60+:

Altered state of consciousness (altered state of mind)
Asthenia (weakness)
Decreased appetite
Depressed level of consciousness
Diarrhoea
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Haematemesis (vomiting of blood)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Influenza

What are the existing conditions these people have? *

Hepatitis C: 31 people, 72.09%
Pain: 4 people, 9.30%
Insomnia (sleeplessness): 3 people, 6.98%
Diabetes: 3 people, 6.98%
Cardiac Failure: 3 people, 6.98%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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