Sevoflurane and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sevoflurane (sevoflurane) and Diphen (diphenhydramine hydrochloride). Common drug interactions include hepatomegaly among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Sevoflurane and Diphen. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Sevoflurane?

Sevoflurane has active ingredients of sevoflurane. eHealthMe is studying from 9,513 Sevoflurane users. Check the latest studies of Sevoflurane.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 11, 2026

59 people who take Sevoflurane and Diphen together, and have interactions are studied.

Sevoflurane and Diphen drug interactions.

What are the common drug interactions of Sevoflurane and Diphen, by gender? *:

female:

Hepatomegaly (abnormal enlargement of the liver)
Hyperkalaemia (damage to or disease of the kidney)
Hypertrophy (increase in the volume of an organ or tissue due to the enlargement of its component cells)
Implant site reaction
Liver fatty (fat deposition of liver)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Oxygen saturation decreased
Pleural effusion (water on the lungs)

male:

Hypotension (abnormally low blood pressure)
Left ventricular dysfunction
Bloody discharge
Erythema (redness of the skin)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Hyperkalaemia (damage to or disease of the kidney)
Infection
Pain
Purulent discharge (discharge that contains pus)
Skin discolouration (change of skin colour)

What are the common drug interactions of Sevoflurane and Diphen, by age (0-1 to 60+)? *:

0-1:

Sinus node dysfunction (a group of abnormal heart rhythms)
Drug ineffective
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Cardiac arrest
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

2-9:

Electrocardiogram st segment depression
Electrocardiogram t wave biphasic
Hypotension (abnormally low blood pressure)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

10-19:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Dyskinesia (abnormality or impairment of voluntary movement)
Dystonia (abnormal muscle tone)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Nausea (feeling of having an urge to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bloody discharge
Erythema (redness of the skin)
Infection
Pain
Purulent discharge (discharge that contains pus)
Skin discolouration (change of skin colour)
Stoma site reaction (reaction at abdominal opening)
Anaphylactic reaction (serious allergic reaction)

30-39:

Renal tubular necrosis (death of kidney tubules)
Splenomegaly (enlargement of spleen)
Ventricular fibrillation (abnormally irregular heart rhythm)
Abdominal compartment syndrome (increased pressure in abdomen)
Postoperative ileus
Drug hypersensitivity
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Atrioventricular block (heart block)
Cardiac arrest
Fungal infection

40-49:

Retinopathy haemorrhagic (acute damage to the retina of the eye with bleeding)
Anaphylactic reaction (serious allergic reaction)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Post procedural complication
Blindness
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory distress (difficulty in breathing)

50-59:

Hypotension (abnormally low blood pressure)
Left ventricular dysfunction
Drug ineffective
Anaemia of chronic disease
Anisocytosis (patient's red blood cells are of unequal size)
Ataxia (loss of full control of bodily movements)
Blood chloride increased
Blood creatinine increased
Blood phosphorus increased
Blood potassium increased

60+:

Adrenal cortex necrosis (death adrenal cortex tissue)
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Vocal cord disorder
Ascites (accumulation of fluid in the abdominal cavity)
Blood culture positive
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Hyperkalaemia (damage to or disease of the kidney)
Immunosuppressant drug level increased
Implant site reaction

What are the existing conditions these people have? *

Anaesthesia: 15 people, 25.42%
Pain: 7 people, 11.86%
Nausea (feeling of having an urge to vomit): 6 people, 10.17%
General Anaesthesia: 6 people, 10.17%
Respiratory Distress (difficulty in breathing): 5 people, 8.47%
The Flu (the flu is caused by an influenza virus): 4 people, 6.78%
Neuromuscular Blockade: 4 people, 6.78%
High Blood Pressure: 4 people, 6.78%
Headache (pain in head): 4 people, 6.78%
Breathing Sounds - Abnormal (Stridor): 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

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