Silvadene and Klor-con drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Silvadene (silver sulfadiazine) and Klor-con (potassium chloride). Common drug interactions include confusional state among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Silvadene and Klor-con. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Silvadene?

Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.

What is Klor-con?

Klor-con has active ingredients of potassium chloride. It is often used in hypokalemia. eHealthMe is studying from 27,547 Klor-con users. Check the latest studies of Klor-con.



On Jul, 08, 2026

45 people who take Silvadene and Klor-con together, and have interactions are studied.

Silvadene and Klor-con drug interactions.

What are the common drug interactions of Silvadene and Klor-Con, by gender? *:

female:

  1. Confusional state
  2. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  3. Disease progression
  4. Dysphagia (a condition in which swallowing is difficult or painful)
  5. Dyspnoea (difficult or laboured respiration)
  6. Headache (pain in head)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)
  9. Dry eye (lack of adequate tears)
  10. Abdominal distension

male:

  1. Sepsis (a severe blood infection that can lead to organ failure and death)
  2. Asthenia (weakness)
  3. Dyspnoea (difficult or laboured respiration)
  4. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  5. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  6. Injury
  7. Renal failure (kidney dysfunction)
  8. Renal failure acute (rapid kidney dysfunction)
  9. Snoring
  10. Ventricular fibrillation (abnormally irregular heart rhythm)

What are the common drug interactions of Silvadene and Klor-Con, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Cellulitis (infection under the skin)
  2. Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
  3. Gangrene (body tissue dies)
  4. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  5. Perineal abscess
  6. Sepsis (a severe blood infection that can lead to organ failure and death)
  7. Urinary tract infection
  8. Vulval abscess
  9. Vulval cellulitis (inflammation of skin around vagina)
  10. Vulvitis (inflammation of the vulva)

50-59:

  1. Snoring
  2. Thrombocytopenia (decrease of platelets in blood)
  3. Ventricular fibrillation (abnormally irregular heart rhythm)
  4. Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
  5. Dizziness
  6. Gout (uric acid crystals building up in the body)
  7. Haematuria (presence of blood in urine)
  8. Injury
  9. Renal failure (kidney dysfunction)
  10. Skin lesion

60+:

  1. Fall
  2. Asthenia (weakness)
  3. Diarrhoea
  4. Disease progression
  5. Dysphagia (a condition in which swallowing is difficult or painful)
  6. Dyspnoea (difficult or laboured respiration)
  7. Headache (pain in head)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
  10. Pain in extremity

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 26.67%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 17.78%
  3. Pain: 7 people, 15.56%
  4. High Blood Pressure: 6 people, 13.33%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.33%
  6. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 8.89%
  7. Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 8.89%
  8. Weight Decreased: 3 people, 6.67%
  9. Type 2 Diabetes: 3 people, 6.67%
  10. Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Silvadene and Klor-con:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Silvadene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Klor-con:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Silvadene and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Klor-con and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on silver sulfadiazine and potassium chloride (the active ingredients of Silvadene and Klor-con, respectively), and Silvadene and Klor-con (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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