Simbrinza and Entresto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simbrinza (brimonidine tartrate; brinzolamide) and Entresto (sacubitril; valsartan). Common drug interactions include death among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Simbrinza and Entresto. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Simbrinza?

Simbrinza has active ingredients of brimonidine tartrate; brinzolamide. It is often used in glaucoma. eHealthMe is studying from 4,543 Simbrinza users. Check the latest studies of Simbrinza.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,629 Entresto users. Check the latest studies of Entresto.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

27 people who take Simbrinza and Entresto together, and have interactions are studied.

Simbrinza and Entresto drug interactions.

What are the common drug interactions of Simbrinza and Entresto, by gender? *:

female:

Death
Blindness
Cataract (clouding of the lens inside the eye)
Fluid retention (an abnormal accumulation of fluid in the blood)
Fracture
Hypervigilance
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Osteoporosis (bones weak and more likely to break)
Poor quality sleep

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Headache (pain in head)
Intraocular pressure fluctuation
Memory impairment
Myalgia (muscle pain)
Oropharyngeal pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Vertigo
Death

What are the common drug interactions of Simbrinza and Entresto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Death
Balanoposthitis (inflammation of the glands penis and the foreskin)
Palpitations (feelings or sensations that your heart is pounding or racing)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Cardiac failure
Headache (pain in head)
Heart rate irregular
Insomnia (sleeplessness)
Intraocular pressure fluctuation
Memory impairment

What are the existing conditions these people have? *

Type 2 Diabetes: 2 people, 7.41%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 7.41%
Hyperkalemia (damage to or disease of the kidney): 2 people, 7.41%
High Blood Pressure: 2 people, 7.41%
Chronic Kidney Disease: 2 people, 7.41%
Cardiac Failure: 2 people, 7.41%
Calcium Deficiency (lack of calcium): 2 people, 7.41%
Acute Pulmonary Oedema (sudden deposit of fluid in the lung)): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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