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Simcor and Estrace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simcor (niacin; simvastatin) and Estrace (estradiol). Common drug interactions include pruritus among females.

The phase IV clinical study analyzes what interactions people have when they take Simcor and Estrace. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

On Jul, 15, 2026

11 people who take Simcor and Estrace together, and have interactions are studied.

Simcor and Estrace drug interactions.

What are the common drug interactions of Simcor and Estrace, by gender? *:

female:

  1. Pruritus (severe itching of the skin)
  2. Flushing (the warm, red condition of human skin)
  3. Pruritus generalised (generalized itching)
  4. Rash
  5. Abdominal pain upper
  6. Blood glucose increased
  7. Flatulence (flatus expelled through the anus)
  8. Headache (pain in head)
  9. Hepatic enzyme increased
  10. Pain

male:

n/a

What are the common drug interactions of Simcor and Estrace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Hepatic enzyme increased
  2. Pruritus (severe itching of the skin)
  3. Rash
  4. Abdominal pain upper
  5. Flatulence (flatus expelled through the anus)
  6. Headache (pain in head)

60+:

  1. Dry skin
  2. Pain of skin
  3. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  4. Peripheral coldness
  5. Pruritus generalised (generalized itching)
  6. Skin burning sensation

What are the existing conditions these people have? *

  1. Low Density Lipoprotein Increased (cholesterol increased in blood): 2 people, 18.18%
  2. Skin Blushing/flushing (a sudden reddening of the face, neck): 1 person, 9.09%
  3. Ocular Hypertension (intraocular pressure higher than normal): 1 person, 9.09%
  4. Lipoprotein (A) Increased (increased molecules made of proteins and fat): 1 person, 9.09%
  5. Itching: 1 person, 9.09%
  6. Hot Flush (sudden feelings of heat): 1 person, 9.09%
  7. High Blood Pressure: 1 person, 9.09%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
  9. Antinuclear Antibody Increased: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Simcor and Estrace?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Simcor and Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simcor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Simcor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Estrace and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on niacin; simvastatin and estradiol (the active ingredients of Simcor and Estrace, respectively), and Simcor and Estrace (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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