Simcor and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simcor (niacin; simvastatin) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include diarrhoea among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Simcor and Vicodin. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 10, 2026

68 people who take Simcor and Vicodin together, and have interactions are studied.

What are the common drug interactions of Simcor and Vicodin, by gender? *:

female:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Skin burning sensation
Erythema (redness of the skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate increased
Injection site pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Vomiting
Burning sensation

male:

Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)
Skin burning sensation
Weight decreased
Constipation
Insomnia (sleeplessness)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Simcor and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Skin warm

40-49:

Flushing (the warm, red condition of human skin)
Skin burning sensation
Anxiety
Constipation
Diarrhoea
Dry skin
Erythema (redness of the skin)
Flatulence (flatus expelled through the anus)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Hypoxia (low oxygen in tissues)
Injection site reaction
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Libido increased (increased sexual urge to have sex)
Ligament sprain (ligament stretched)
Limb deformity (functional disability of leg)
Lung infection
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)

60+:

Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)
Hypotension (abnormally low blood pressure)
Pancreatitis (inflammation of pancreas)
Peptic ulcer
Presyncope
Weight decreased
Diarrhoea
Heart rate increased
Migraine (headache)

What are the existing conditions these people have? *

High Density Lipoprotein Decreased: 11 people, 16.18%
Low Density Lipoprotein Increased (cholesterol increased in blood): 9 people, 13.24%
High Blood Pressure: 6 people, 8.82%
Back Pain: 6 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.35%
Depression: 5 people, 7.35%
Insomnia (sleeplessness): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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