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Simcor and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simcor (niacin; simvastatin) and Zestril (lisinopril). Common drug interactions include dry skin among females and flushing among males.

The phase IV clinical study analyzes what interactions people have when they take Simcor and Zestril. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Simcor?

Simcor has active ingredients of niacin; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 11,604 Simcor users. Check the latest studies of Simcor.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Jul, 25, 2026

12 people who take Simcor and Zestril together, and have interactions are studied.

Simcor and Zestril drug interactions.

What are the common drug interactions of Simcor and Zestril, by gender? *:

female:

  1. Dry skin
  2. Nausea (feeling of having an urge to vomit)
  3. Chills (felling of cold)
  4. Cystitis (inflammation of the wall of the bladder)
  5. Decreased appetite
  6. Feeling hot
  7. Pruritus (severe itching of the skin)
  8. Flatulence (flatus expelled through the anus)
  9. Flushing (the warm, red condition of human skin)
  10. Diarrhoea

male:

  1. Flushing (the warm, red condition of human skin)
  2. Pruritus (severe itching of the skin)
  3. Dysphagia (a condition in which swallowing is difficult or painful)
  4. Feeling hot
  5. Muscle spasms (muscle contraction)

What are the common drug interactions of Simcor and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Flushing (the warm, red condition of human skin)
  2. Constipation
  3. Dry skin
  4. Flatulence (flatus expelled through the anus)

50-59:

  1. Feeling hot
  2. Flushing (the warm, red condition of human skin)
  3. Pruritus (severe itching of the skin)

60+:

  1. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  2. Diarrhoea
  3. Flatulence (flatus expelled through the anus)
  4. Nausea (feeling of having an urge to vomit)
  5. Feeling hot
  6. Flushing (the warm, red condition of human skin)
  7. Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

  1. Low Density Lipoprotein Increased (cholesterol increased in blood): 5 people, 41.67%
  2. High Density Lipoprotein Decreased: 4 people, 33.33%
  3. Pain: 1 person, 8.33%
  4. Migraine (headache): 1 person, 8.33%
  5. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 8.33%
  6. Borderline Glaucoma: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Simcor and Zestril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Simcor and Zestril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simcor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zestril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Simcor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zestril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on niacin; simvastatin and lisinopril (the active ingredients of Simcor and Zestril, respectively), and Simcor and Zestril (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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