Simethicone and Santyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simethicone (simethicone) and Santyl (collagenase). Common drug interactions include febrile neutropenia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Simethicone and Santyl. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Simethicone?

Simethicone has active ingredients of simethicone. It is often used in gas. eHealthMe is studying from 6,762 Simethicone users. Check the latest studies of Simethicone.

What is Santyl?

Santyl has active ingredients of collagenase. eHealthMe is studying from 1,479 Santyl users. Check the latest studies of Santyl.

On Jul, 15, 2026

12 people who take Simethicone and Santyl together, and have interactions are studied.

Simethicone and Santyl drug interactions.

What are the common drug interactions of Simethicone and Santyl, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Anaemia (lack of blood)
Hypokalaemia (low potassium)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
White blood cell count decreased
Pulmonary oedema (fluid accumulation in the lungs)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Constipation

male:

Anaemia (lack of blood)
Abdominal abscess (collection of pus in abdomen)
Malignant neoplasm progression (cancer tumour came back)
Platelet count decreased
Pneumonia
Septic shock (shock due to blood infection)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Asthenia (weakness)
Bone marrow failure
Cardiomegaly (increased size of heart than normal)

What are the common drug interactions of Simethicone and Santyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
White blood cell count decreased

50-59:

n/a

60+:

Anaemia (lack of blood)
Febrile neutropenia (fever with reduced white blood cells)
Large intestine perforation (hole in large intestine)
Malignant neoplasm progression (cancer tumour came back)
Platelet count decreased
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Septic shock (shock due to blood infection)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the existing conditions these people have? *

Pain: 8 people, 66.67%
Nausea (feeling of having an urge to vomit): 6 people, 50.00%
Insomnia (sleeplessness): 5 people, 41.67%
Nausea And Vomiting: 4 people, 33.33%
Constipation: 4 people, 33.33%
Flatulence (flatus expelled through the anus): 4 people, 33.33%
Bone Pain: 3 people, 25.00%
White Blood Cell Count Increased: 3 people, 25.00%
Ovarian Cancer (cancer of ovary): 3 people, 25.00%
Wound: 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

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