Sinemet cr and Elavil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet cr (carbidopa; levodopa) and Elavil (amitriptyline hydrochloride). Common drug interactions include obsessive-compulsive disorder among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet cr and Elavil. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet cr?

Sinemet cr has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 2,852 Sinemet cr users. Check the latest studies of Sinemet cr.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

On Jul, 11, 2026

12 people who take Sinemet cr and Elavil together, and have interactions are studied.

Sinemet cr and Elavil drug interactions.

What are the common drug interactions of Sinemet Cr and Elavil, by gender? *:

female:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling
Fall
Weight increased
Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule)

male:

Cardiac arrest
Cardiac failure congestive
Hyperphagia (an abnormal appetite for food)
Hypersexuality
Myopathy (a muscular disease in which the muscle fibres do not function)
Nausea (feeling of having an urge to vomit)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling
Pulmonary oedema (fluid accumulation in the lungs)
Weight increased

What are the common drug interactions of Sinemet Cr and Elavil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Fall
Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule)
Injection site erythema (redness at injection site)
Joint injury
Weight increased

60+:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Cardiac arrest
Sedation
Sleep attacks
Sleep disorder
Weight increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Fall

What are the existing conditions these people have? *

Insomnia (sleeplessness): 4 people, 33.33%
Urinary Tract Infection: 3 people, 25.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 25.00%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 3 people, 25.00%
Stress And Anxiety: 3 people, 25.00%
Oedema (fluid collection in tissue): 3 people, 25.00%
Constipation: 3 people, 25.00%
Seasonal Allergy (allergic condition due to certain season): 3 people, 25.00%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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