Sinemet and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include drug ineffective among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Excedrin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 11, 2026

24 people who take Sinemet and Excedrin together, and have interactions are studied.

What are the common drug interactions of Sinemet and Excedrin, by gender? *:

female:

Drug ineffective
Fall
Anxiety
Depression
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Arthralgia (joint pain)
Pathological gambling
Gait disturbance
Aphasia (damage to the parts of the brain that control language)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

Fall
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Fatigue (feeling of tiredness)
Gait disturbance
Haematocrit decreased
Hallucination (an experience involving the perception of something not present)
Heart rate increased
Hypokalaemia (low potassium)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Sinemet and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Balance disorder
Blood pressure decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Dry skin
Dysarthria (speech disorder)
Fall

40-49:

Arthralgia (joint pain)
Pain in limb

50-59:

Drug ineffective
Fall
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Hypersomnia (excessive daytime sleepiness (eds))
Memory impairment
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Anaphylactic reaction (serious allergic reaction)
Anxiety
Arthralgia (joint pain)
Chest pain

60+:

Aphasia (damage to the parts of the brain that control language)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypoaesthesia (reduced sense of touch or sensation)
Constipation
Dysarthria (speech disorder)
Gait disturbance
Hemiparesis (weakness on one side of the body)
Abasia (inability to walk)
Delusion (a false belief or opinion)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

What are the existing conditions these people have? *

Pain: 10 people, 41.67%
Depression: 7 people, 29.17%
Alcoholism (problems with alcohol): 5 people, 20.83%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 20.83%
Quit Smoking: 5 people, 20.83%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 20.83%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 20.83%
Movement - Uncontrolled Or Slow: 3 people, 12.50%
Oedema Peripheral (superficial swelling): 3 people, 12.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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