Sinemet and Repatha drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Repatha (evolocumab). Common drug interactions include impaired healing among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Repatha. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

17 people who take Sinemet and Repatha together, and have interactions are studied.

What are the common drug interactions of Sinemet and Repatha, by gender? *:

female:

Impaired healing
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Injection site pain
Wound
Death
Muscular weakness (muscle weakness)
Abdominal pain
Asthenia (weakness)
Balance disorder
Chills (felling of cold)

male:

Nausea (feeling of having an urge to vomit)
Haemorrhage subcutaneous (bleeding from skin)
Confusional state
Death
Hallucination (an experience involving the perception of something not present)
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Injection site erythema (redness at injection site)
Injection site swelling
Insomnia (sleeplessness)

What are the common drug interactions of Sinemet and Repatha, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Impaired healing
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Injection site pain
Wound
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Insomnia (sleeplessness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

60+:

Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)
Sinus congestion (blockage of sinus)
Abdominal pain
Asthenia (weakness)
Balance disorder
Chest pain
Chills (felling of cold)
Haemoglobin decreased
Hallucination (an experience involving the perception of something not present)

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 17.65%
Upper-Airway Cough Syndrome: 2 people, 11.76%
Depression: 2 people, 11.76%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 11.76%
Hypersensitivity: 2 people, 11.76%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 11.76%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 11.76%
Blood Pressure Abnormal: 1 person, 5.88%
Breast Cancer: 1 person, 5.88%
Cardiac Murmur (an heart sound in valve abnormality): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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