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Sinemet and Rezulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Rezulin (troglitazone). Common drug interactions include bronchitis among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Rezulin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

On Jul, 24, 2026

17 people who take Sinemet and Rezulin together, and have interactions are studied.

Sinemet and Rezulin drug interactions.

What are the common drug interactions of Sinemet and Rezulin, by gender? *:

female:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  3. Cellulitis (infection under the skin)
  4. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  5. Confusion
  6. Dementia (madness)
  7. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  8. Difficulty in walking
  9. Dizziness (excl vertigo)
  10. Drug toxicity

male:

  1. Cardiac failure congestive
  2. Cardiomegaly (increased size of heart than normal)
  3. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  4. Pleural effusion (water on the lungs)
  5. Agitation (state of anxiety or nervous excitement)
  6. Ammonia increased
  7. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  8. Blood bilirubin increased
  9. Blood creatine phosphokinase increased
  10. Blood ph decreased

What are the common drug interactions of Sinemet and Rezulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Cardiac failure congestive
  2. Hepatic failure (liver failure)
  3. Encephalopathy (functioning of the brain is affected by some agent or condition)
  4. Fall
  5. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  6. Humerus fracture (injury to the upper arm bone)
  7. Weakness
  8. Weight increased
  9. Agitation (state of anxiety or nervous excitement)
  10. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and Rezulin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sinemet and Rezulin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Rezulin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sinemet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rezulin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa and troglitazone (the active ingredients of Sinemet and Rezulin, respectively), and Sinemet and Rezulin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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