Sinemet and Sudafed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Sudafed (pseudoephedrine hydrochloride). Common drug interactions include headache among females and cholelithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Sudafed. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

On Jul, 13, 2026

28 people who take Sinemet and Sudafed together, and have interactions are studied.

What are the common drug interactions of Sinemet and Sudafed, by gender? *:

female:

Headache (pain in head)
Tremor (trembling or shaking movements in one or more parts of your body)
Feeling hot
Vomiting
Nausea (feeling of having an urge to vomit)
Facial bones fracture (bone fracture of face)
Fall
Hyperhidrosis (abnormally increased sweating)
Acute myocardial infarction (acute heart attack)
Cardiac arrest

male:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Death
Depression
Dizziness
Drug hypersensitivity
Drug maladministration
Dyskinesia oesophageal (abnormality or impairment of voluntary movement of oesophageal)
Fall
Gallbladder disorder
Headache (pain in head)

What are the common drug interactions of Sinemet and Sudafed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Facial paralysis (loss of function of face muscle)

40-49:

n/a

50-59:

Dyskinesia (abnormality or impairment of voluntary movement)
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cardiac disorder
Chest pain
Hypokinesia (decreased bodily movement)
Pain in limb

60+:

Headache (pain in head)
Fall
Haematoma (collection of blood outside the blood vessels)
Sudden cardiac death
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood glucose increased
Loss of consciousness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Aphasia (damage to the parts of the brain that control language)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.71%
Movement - Uncontrolled Or Slow: 3 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 10.71%
Nasal Obstruction (blockage of nose): 2 people, 7.14%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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