Sinemet and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Zelnorm (tegaserod maleate). Common drug interactions include disturbance in attention among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Zelnorm. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Jul, 13, 2026

20 people who take Sinemet and Zelnorm together, and have interactions are studied.

What are the common drug interactions of Sinemet and Zelnorm, by gender? *:

female:

Disturbance in attention
Drooling (drop saliva uncontrollably from the mouth)
Dysgraphia (impaired ability to learn to write)
Dysphagia (a condition in which swallowing is difficult or painful)
Early satiety (feeling full before completing a normal sized meal)
Encephalitis (inflammation of the brain)
Euphoric mood (excessively happy but may become angry or irritable)
Exostosis (formation of new bone on the surface of a bone)
Faecaloma (hard mass of fecal matter)
Fall

male:

Abdominal discomfort
Asthenia (weakness)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Vomiting
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Blood chloride decreased

What are the common drug interactions of Sinemet and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Bezoar (mass found trapped in the gastrointestinal system)
Blindness
Candidiasis (candidiasis or thrush is a fungal infection)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Change of bowel habit
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colitis (inflammation of colon)

50-59:

Hypotension (abnormally low blood pressure)
Abdominal discomfort
Asthenia (weakness)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Circulatory collapse
Diabetes mellitus inadequate control
Dizziness
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

60+:

Aphasia (damage to the parts of the brain that control language)
Asthma
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased activity
Delirium (wild excitement)
Diabetic nephropathy (diabetic kidney disease)
Diplopia (double vision)
Drug ineffective
Faecaloma (hard mass of fecal matter)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 4 people, 20.00%
Constipation: 4 people, 20.00%
Diabetes: 3 people, 15.00%
Diabetic Gastroparesis (paralysis of the muscles of the stomach caused by diabetes): 3 people, 15.00%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 3 people, 15.00%
Pain: 3 people, 15.00%
Nausea And Vomiting: 3 people, 15.00%
Urinary Tract Infection: 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and Zelnorm?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously