Sinemet and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet (carbidopa; levodopa) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include anaemia haemolytic autoimmune among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Sinemet and Zosyn. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 20, 2026

16 people who take Sinemet and Zosyn together, and have interactions are studied.

What are the common drug interactions of Sinemet and Zosyn, by gender? *:

female:

Anaemia haemolytic autoimmune (a condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)
Chronic kidney disease
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Lactic acidosis (low ph in body tissues)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tonic clonic movements (generalized seizure that affects the entire brain)
Unresponsive to stimuli

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
International normalised ratio increased
Hepatic failure (liver failure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Multi-organ failure (multisystem organ failure)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Pulmonary oedema (fluid accumulation in the lungs)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Subcutaneous abscess

What are the common drug interactions of Sinemet and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Subcutaneous abscess

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dysphagia (a condition in which swallowing is difficult or painful)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hepatic failure (liver failure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Multi-organ failure (multisystem organ failure)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 37.50%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 12.50%
High Blood Cholesterol: 2 people, 12.50%
Diabetes: 2 people, 12.50%
Weight Decreased: 1 person, 6.25%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 6.25%
Anaemia (lack of blood): 1 person, 6.25%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 1 person, 6.25%
Blood Glucose Fluctuation: 1 person, 6.25%
Blood Pressure Abnormal: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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