Singulair and Artane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Singulair (montelukast sodium) and Artane (trihexyphenidyl hydrochloride). Common drug interactions include cough among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Singulair and Artane. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

What is Artane?

Artane has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,619 Artane users. Check the latest studies of Artane.

On Jul, 07, 2026

69 people who take Singulair and Artane together, and have interactions are studied.

What are the common drug interactions of Singulair and Artane, by gender? *:

female:

Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fatigue (feeling of tiredness)
Hepatic steatosis (fatty liver disease)
Hot flush (sudden feelings of heat)
Intervertebral disc degeneration (spinal disc degeneration)
Joint sprain (an injury to joint surrounding flexible fibres)
Lordosis (outward curve of the back bone)
Myalgia (muscle pain)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastroenteritis (inflammation of stomach and intestine)
Abnormal sensation in eye
Hypertriglyceridaemia (excess of triglycerides in the blood)
Affect lability (emotional incontinence)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Pyrexia (fever)
Blood alkaline phosphatase increased

What are the common drug interactions of Singulair and Artane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Activities of daily living impaired
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation
Discomfort
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysarthria (speech disorder)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Lethargy (tiredness)
Pain in extremity
Salivary hypersecretion (excess saliva secretion)

10-19:

Nephrolithiasis (calculi in the kidneys)

20-29:

Arthralgia (joint pain)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug abuse
Enuresis (repeated inability to control urination)
Gastroenteritis (inflammation of stomach and intestine)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Insomnia (sleeplessness)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastroenteritis (inflammation of stomach and intestine)
Insomnia (sleeplessness)
Enuresis (repeated inability to control urination)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Renal impairment (severely reduced kidney function)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pruritus genital (uneasy irritation of the skin of the vagina and the surrounding area)
Stomatitis (inflammation of mucous membrane of mouth)

40-49:

Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fatigue (feeling of tiredness)
Hepatic steatosis (fatty liver disease)
Hot flush (sudden feelings of heat)
Hyperglycaemia (high blood sugar)
Intervertebral disc degeneration (spinal disc degeneration)
Joint sprain (an injury to joint surrounding flexible fibres)

50-59:

Affect lability (emotional incontinence)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Gamma-glutamyltransferase increased
Pyrexia (fever)
Aggression
Agitation (state of anxiety or nervous excitement)
Blood alkaline phosphatase increased
Blood cholinesterase decreased

60+:

Chronic obstructive airways disease
Ear pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebrovascular disorder (disease of brain)
Dehydration (dryness resulting from the removal of water)
Dizziness postural
Dysphonia (speech disorder attributable to a disorder of phonation)
Exposed bone in jaw

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 32 people, 46.38%
Hiv Infection: 31 people, 44.93%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 31 people, 44.93%
Dyslipidaemia (abnormal amount of lipids): 31 people, 44.93%
Diabetes: 9 people, 13.04%
Abnormal Sensation In Eye: 8 people, 11.59%
Pain: 4 people, 5.80%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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