Singulair and Macitentan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Singulair (montelukast sodium) and Macitentan (macitentan). Common drug interactions include pulmonary oedema among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Singulair and Macitentan. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,751 Singulair users. Check the latest studies of Singulair.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

On Feb, 19, 2026

36 people who take Singulair and Macitentan together, and have interactions are studied.

Singulair and Macitentan drug interactions.

What are the common drug interactions of Singulair and Macitentan, by gender? *:

female:

Pulmonary oedema (fluid accumulation in the lungs)
Renal disorder (kidney disease)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory rate increased (excess breathing rate/min)
Rib fracture
Right ventricular failure (right half of the heart fails to work)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Dyspnoea (difficult or laboured respiration)

male:

Pneumonia
Cardiac disorder
Cirrhosis alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism)
Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
Muscular weakness (muscle weakness)
Osteomyelitis (infection of bone)
Pain in extremity
Pancreatitis chronic (chronic inflammation of pancreas)
Peripheral swelling
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

What are the common drug interactions of Singulair and Macitentan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Gingival pain (gum pain)
Haemorrhage (bleeding)
Swelling

20-29:

n/a

30-39:

n/a

40-49:

Abasia (inability to walk)
Abdominal pain upper
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood bilirubin increased
Blood glucose decreased
Body temperature increased
Cardiomegaly (increased size of heart than normal)
Chills (felling of cold)
Cough

50-59:

Fatigue (feeling of tiredness)
Hypersensitivity
Pneumonia
Sinus disorder (disease of sinus)
Sinusitis (inflammation of sinus)
Death
Abdominal pain upper
Alcohol abuse
Aspartate aminotransferase increased
Blood albumin decreased

60+:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dizziness
Epistaxis (bleed from the nose)
Hypersensitivity
Lipase increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pancreatitis (inflammation of pancreas)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 22 people, 61.11%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 13.89%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 5.56%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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