Singulair and Rezulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Singulair (montelukast sodium) and Rezulin (troglitazone). Common drug interactions include diaphragmatic paralysis among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Singulair and Rezulin. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

On Aug, 01, 2026

23 people who take Singulair and Rezulin together, and have interactions are studied.

Singulair and Rezulin drug interactions.

What are the common drug interactions of Singulair and Rezulin, by gender? *:

female:

Diaphragmatic paralysis (acquired dysfunction of the phrenic nerve)
Diarrhoea
Electrocardiogram poor r-wave progression
Electrolyte imbalance
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Flat affect (absence of emotional response to a situation)
Gastro-oesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematocrit
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatitis a antibody positive

male:

Back pain
Blood cholesterol increased
Injury
Muscle cramps (painful sensations caused by muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pruritus (severe itching of the skin)
Renal cyst (kidney cyst)
Urticaria (rash of round, red welts on the skin that itch intensely)
Abscess (pus)
Arthralgia (joint pain)

What are the common drug interactions of Singulair and Rezulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Blood pressure increased
Haemorrhage (bleeding)
Headache (pain in head)
Jaundice cholestatic
Post-operative haemorrhage (post-operative bleeding)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood bilirubin increased
Cholangitis (infection of the bile duct)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

60+:

Haematocrit decreased
Haemoglobin decreased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Muscle cramps (painful sensations caused by muscle contraction)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Urinary tract infection
Aspartate aminotransferase increased
Blood urea increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%
Otitis Media (inflammation of the middle ear): 2 people, 8.70%
Insomnia (sleeplessness): 2 people, 8.70%
Diabetes: 2 people, 8.70%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 8.70%
Back Pain: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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