Singulair and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Singulair (montelukast sodium) and Saphris (asenapine maleate). Common drug interactions include fatigue among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Singulair and Saphris. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

On Jul, 25, 2026

72 people who take Singulair and Saphris together, and have interactions are studied.

Singulair and Saphris drug interactions.

What are the common drug interactions of Singulair and Saphris, by gender? *:

female:

Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Intervertebral disc disorder (spinal disc disorder)
Jaw disorder (jaw disease)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Moaning (a low, sustained, mournful cry)

male:

Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Coma (state of unconsciousness lasting more than six hours)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Haematemesis (vomiting of blood)
Malaise (a feeling of general discomfort or uneasiness)
Upper-airway cough syndrome
Asthenia (weakness)

What are the common drug interactions of Singulair and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Feeling drunk
Gait disturbance
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Vision blurred

20-29:

Asthenia (weakness)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Sleep disorder

30-39:

Vertigo
Diplopia (double vision)
Headache (pain in head)
Heterophoria (type of eye condition in which the directions that the eyes are pointing at rest position, when not performing binocular fusion)
Hypoaesthesia (reduced sense of touch or sensation)
Nystagmus (a condition of involuntary eye movement)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Visual field defect
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)

40-49:

Sleep disorder
Sleep-related eating disorder (abnormal eating patterns during the night)
Snoring
Somnambulism (sleep walking)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Surgery
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Type 2 diabetes mellitus
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Gait disturbance
Nerve compression
Pleural effusion (water on the lungs)
Pulmonary mass
Pulmonary oedema (fluid accumulation in the lungs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vertigo positional
Balance disorder
Chronic kidney disease

60+:

Constipation
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Jaw disorder (jaw disease)
Road traffic accident
Tardive dyskinesia (a disorder that involves involuntary movements)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 18.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 18.06%
Depression: 12 people, 16.67%
Bipolar Disorder (mood disorder): 11 people, 15.28%
Stress And Anxiety: 10 people, 13.89%
High Blood Pressure: 7 people, 9.72%
Sleep Disorder: 5 people, 6.94%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.94%
Insomnia (sleeplessness): 5 people, 6.94%
Immunodeficiency Common Variable: 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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