Sirolimus and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sirolimus (sirolimus) and Actos (pioglitazone hydrochloride). Common drug interactions include abdominal discomfort among females and deformity among males.

The phase IV clinical study analyzes what interactions people have when they take Sirolimus and Actos. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 24, 2026

14 people who take Sirolimus and Actos together, and have interactions are studied.

What are the common drug interactions of Sirolimus and Actos, by gender? *:

female:

Abdominal discomfort
Hospitalisation
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Lung neoplasm malignant (cancer tumour of lung)
Oxygen saturation decreased
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Vomiting
Chest pain

male:

Deformity (disfigurement)
Discomfort
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain
Pruritus (severe itching of the skin)
Scar
Skin discolouration (change of skin colour)
Skin fissures (a crack in the skin)
Skin hypertrophy (skin cells enlarges)

What are the common drug interactions of Sirolimus and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Deformity (disfigurement)
Discomfort
Dry skin
Erythema (redness of the skin)
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Abdominal discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea exertional (breathlessness or shortness of breath)
Pulmonary oedema (fluid accumulation in the lungs)
Death
Thrombocytopenia (decrease of platelets in blood)
Hospitalisation
Lung neoplasm malignant (cancer tumour of lung)
Oxygen saturation decreased
Lung disorder (lung disease)

What are the existing conditions these people have? *

Hyperkalemia (damage to or disease of the kidney): 8 people, 57.14%
Sinusitis (inflammation of sinus): 2 people, 14.29%
Sinus Congestion (blockage of sinus): 2 people, 14.29%
Pain: 2 people, 14.29%
Oedema (fluid collection in tissue): 2 people, 14.29%
Middle Ear Effusion (fluid in middle ear): 2 people, 14.29%
Lipids Increased (excess lipid in body): 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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