Sirolimus and Aranesp drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sirolimus (sirolimus) and Aranesp (darbepoetin alfa). Common drug interactions include hydronephrosis among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Sirolimus and Aranesp. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Aranesp?

Aranesp has active ingredients of darbepoetin alfa. It is often used in anemia. eHealthMe is studying from 54,331 Aranesp users. Check the latest studies of Aranesp.

On Jul, 25, 2026

33 people who take Sirolimus and Aranesp together, and have interactions are studied.

Sirolimus and Aranesp drug interactions.

What are the common drug interactions of Sirolimus and Aranesp, by gender? *:

female:

Hydronephrosis (water inside the kidney)
Bleeding time prolonged
Colon cancer
Ureteric obstruction
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Haemoglobin decreased
Post transplant lymphoproliferative disorder
Blood iron decreased
Epstein-barr virus associated lymphoproliferative disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus)
Abdominal distension

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pneumonia
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ureteric stenosis (abnormal narrowing or contraction of a duct or canal)
Laryngitis bacterial (inflammation of the larynx caused by a bacterial infection)
Laryngitis fungal (inflammation of the larynx due to fungal infection)
Oesophageal candidiasis (fungal infection of oesophagus)
General physical health deterioration (weak health status)
Pain
Wound dehiscence (a surgical incision reopens either internally or externally)

What are the common drug interactions of Sirolimus and Aranesp, by age (0-1 to 60+)? *:

0-1:

Anaemia (lack of blood)
Herpes simplex (herpes simplex is a common viral infection)
Reticulocytopenia (an abnormal decrease of reticulocytes in the body)

2-9:

n/a

10-19:

n/a

20-29:

Foetal heart rate decreased
Hydronephrosis (water inside the kidney)
Hypertension (high blood pressure)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Transplant rejection (a transplant material is not worked)
Urinary tract infection

30-39:

Abdominal distension
Abscess (pus)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Back pain
Bacterial infection
Bacteriuria (presence of bacteria in urine)
Bladder spasm

40-49:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bladder cancer
Death
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Septic shock (shock due to blood infection)

50-59:

Myopathy (a muscular disease in which the muscle fibres do not function)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)
Onychomycosis (fungal infection of the nail)
Oral candidiasis (fungal infection of mouth)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)

60+:

Abdominal hernia
Acute abdomen
Ureteric stenosis (abnormal narrowing or contraction of a duct or canal)
Pneumonia
Laryngitis bacterial (inflammation of the larynx caused by a bacterial infection)
Laryngitis fungal (inflammation of the larynx due to fungal infection)
Oesophageal candidiasis (fungal infection of oesophagus)
Wound dehiscence (a surgical incision reopens either internally or externally)
Infection in an immunocompromised host
Suture rupture

What are the existing conditions these people have? *

Immunodeficiency Disorders: 4 people, 12.12%
High Blood Pressure: 4 people, 12.12%
High Blood Cholesterol: 4 people, 12.12%
Nephrogenic Anaemia (anaemia due to kidney disease): 3 people, 9.09%
Anaemia (lack of blood): 3 people, 9.09%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 6.06%
Osteoporosis (bones weak and more likely to break): 2 people, 6.06%
Indigestion: 2 people, 6.06%
Diabetes: 2 people, 6.06%
Chronic Kidney Disease: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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