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Sirolimus and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sirolimus (sirolimus) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include pneumonitis among females and cytomegalovirus chorioretinitis among males.

The phase IV clinical study analyzes what interactions people have when they take Sirolimus and Fluoxetine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,824 Fluoxetine users. Check the latest studies of Fluoxetine.

On Aug, 03, 2026

28 people who take Sirolimus and Fluoxetine together, and have interactions are studied.

Sirolimus and Fluoxetine drug interactions.

What are the common drug interactions of Sirolimus and Fluoxetine, by gender? *:

female:

  1. Pneumonitis (inflammation of the walls of the alveoli in the lungs)
  2. Pyrexia (fever)
  3. Blood pressure increased
  4. Diarrhoea
  5. Pain
  6. Renal impairment (severely reduced kidney function)
  7. Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
  8. Asthenia (weakness)
  9. Blood creatinine increased
  10. Body temperature decreased

male:

  1. Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
  2. Diarrhoea
  3. Aspartate aminotransferase increased
  4. Blood bilirubin increased
  5. Blood lactate dehydrogenase increased
  6. Blood urea increased
  7. Cutaneous vasculitis (an inflammatory process affecting the vessel wall that leads to its damage)
  8. Cytomegalovirus viraemia (cytomegalo virus in blood stream)
  9. Nephropathy toxic (damage to kidney due to toxins)
  10. Periodontitis (inflammation of the tissue around the teeth)

What are the common drug interactions of Sirolimus and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Blood iron increased
  2. Drug level increased
  3. Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
  4. Asthenia (weakness)
  5. Blood creatinine increased
  6. Blood pressure increased
  7. Body temperature decreased
  8. Chills (felling of cold)
  9. Dehydration (dryness resulting from the removal of water)
  10. Diarrhoea

30-39:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)
  4. Infection
  5. Iridocyclitis (inflammation of the iris and ciliary body of the eye)
  6. Oesophageal rupture (break in oesophagus)
  7. Pneumonia

40-49:

  1. Blood pressure increased
  2. Brain natriuretic peptide increased
  3. Chest discomfort
  4. Chest pain
  5. Cough
  6. Diarrhoea
  7. Dyspnoea (difficult or laboured respiration)
  8. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  9. Oedema peripheral (superficial swelling)
  10. Oropharyngeal pain

50-59:

  1. Diarrhoea
  2. Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
  3. Drug resistance (reduction in effectiveness of a drug)
  4. Flushing (the warm, red condition of human skin)
  5. Idiopathic pneumonia syndrome (pneumonia-like symptoms)
  6. Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
  7. Skin discolouration (change of skin colour)
  8. Weight decreased
  9. Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
  10. Cytomegalovirus viraemia (cytomegalo virus in blood stream)

60+:

  1. Alanine aminotransferase increased
  2. Anaemia (lack of blood)
  3. White blood cell count increased
  4. Blood pressure increased
  5. Confusional state
  6. Cough
  7. Dementia (madness)
  8. Hypertension (high blood pressure)
  9. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  10. Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

  1. Iron Overload: 5 people, 17.86%
  2. Pain: 4 people, 14.29%
  3. Immunodeficiency Disorders: 3 people, 10.71%
  4. Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 3 people, 10.71%
  5. Cytomegalovirus Chorioretinitis (infection of choroid and retina of the eye from virus): 3 people, 10.71%
  6. Hypersensitivity: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Sirolimus and Fluoxetine?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sirolimus and Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sirolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sirolimus and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fluoxetine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sirolimus and fluoxetine hydrochloride (the active ingredients of Sirolimus and Fluoxetine, respectively), and Sirolimus and Fluoxetine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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