Sirolimus and Midazolam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sirolimus (sirolimus) and Midazolam (midazolam). Common drug interactions include aplastic anaemia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Sirolimus and Midazolam. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Midazolam?

Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.

On Jul, 14, 2026

42 people who take Sirolimus and Midazolam together, and have interactions are studied.

Sirolimus and Midazolam drug interactions.

What are the common drug interactions of Sirolimus and Midazolam, by gender? *:

female:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Drug ineffective
Disease recurrence
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Flushing (the warm, red condition of human skin)
Heart rate increased
Multiple-drug resistance
Respiratory rate increased (excess breathing rate/min)
Blood pressure decreased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Anaemia (lack of blood)
Eczema infantile (allergic inflammation of the skin in young children)
Nephropathy toxic (damage to kidney due to toxins)
Diarrhoea
Nervousness
Somnambulism (sleep walking)
Chest pain
Complement factor increased
Electrocardiogram st segment elevation
Encephalitis autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain)

What are the common drug interactions of Sirolimus and Midazolam, by age (0-1 to 60+)? *:

0-1:

Anaemia (lack of blood)
Eczema infantile (allergic inflammation of the skin in young children)
Herpangina (mouth blisters)
Neonatal infection (infection to neonate)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Drug ineffective
Blood pressure decreased
Disease recurrence
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Flushing (the warm, red condition of human skin)

2-9:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Mucosal inflammation (infection of mucous membrane)

10-19:

Drug ineffective
Necrotising colitis (inflammation in the intestines (usually the colon) that can be life-threatening)
Septic shock (shock due to blood infection)
Leukopenia (less number of white blood cells in blood)
Cardiac arrest

20-29:

Dyspnoea (difficult or laboured respiration)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)
Death

30-39:

n/a

40-49:

Multiple-drug resistance
Complement factor increased
Encephalitis autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain)
Septic shock (shock due to blood infection)

50-59:

n/a

60+:

Chest pain
Electrocardiogram st segment elevation

What are the existing conditions these people have? *

Partial Seizures (seizures which affect only a part of the brain at onset): 7 people, 16.67%
Bone Marrow Conditioning Regimen: 6 people, 14.29%
Stress And Anxiety: 6 people, 14.29%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 6 people, 14.29%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 14.29%
Encephalitis Autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain): 5 people, 11.90%
Fever: 4 people, 9.52%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 4 people, 9.52%
High Blood Pressure: 4 people, 9.52%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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