Sirolimus and Prilosec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sirolimus (sirolimus) and Prilosec (omeprazole). Common drug interactions include blood cholesterol increased among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Sirolimus and Prilosec. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,286 Prilosec users. Check the latest studies of Prilosec.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

83 people who take Sirolimus and Prilosec together, and have interactions are studied.

Sirolimus and Prilosec drug interactions.

What are the common drug interactions of Sirolimus and Prilosec, by gender? *:

female:

Blood cholesterol increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cough
Hypersensitivity
Pulmonary mycosis (lung infection caused by yeast-like fungi)
Secretion discharge
Sinusitis (inflammation of sinus)
Vomiting
Asthenia (weakness)
Headache (pain in head)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fall
Pneumonia
Acidosis (build-up of carbon dioxide in the blood)
Renal tubular necrosis (death of kidney tubules)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Headache (pain in head)

What are the common drug interactions of Sirolimus and Prilosec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Aspartate aminotransferase increased
Blood urea increased
Blood urea nitrogen/creatinine ratio increased
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hospitalisation
Parotitis (inflammation of a parotid gland)
Salivary gland calculus (stone in salivary gland)
Sialoadenitis (inflammation of a salivary gland)
Viraemia (presence of a virus in the blood stream)

20-29:

Ear infection
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Blood cholesterol increased
Cough
Hypersensitivity
Sinusitis (inflammation of sinus)
Surgery
Blood glucose increased

30-39:

Chills (felling of cold)
Dyskinesia (abnormality or impairment of voluntary movement)
Eye disorder
Hemiplegia (paralysis of one side of the body)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vertigo
Vomiting

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Nephrogenic anaemia (anaemia due to kidney disease)
Cardiovascular disorder (heart diseases)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vomiting
Acarodermatitis (skin inflammation caused by mites (acarids))
Alopecia (absence of hair from areas of the body)
Anxiety

50-59:

Aphthous stomatitis (mouth ulcer)
Arteriosclerosis (thickening and hardening of arteries)
Asthma
Back pain
Blood creatine phosphokinase increased
Blood creatine phosphokinase mb increased
Blood glucose fluctuation
Blood phosphorus decreased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal discomfort
Anaemia macrocytic (a macrocytic class of anaemia)
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Bone neoplasm malignant (cancer of bone)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardiac failure congestive

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 9.64%
High Blood Cholesterol: 8 people, 9.64%
Pain: 5 people, 6.02%
Oedema (fluid collection in tissue): 5 people, 6.02%
Infection: 5 people, 6.02%
Diabetes: 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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