Sitagliptin and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sitagliptin (sitagliptin) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include oedema peripheral among females and myelitis among males.

The phase IV clinical study analyzes what interactions people have when they take Sitagliptin and Valacyclovir. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Sitagliptin?

Sitagliptin has active ingredients of sitagliptin. eHealthMe is studying from 3,933 Sitagliptin users. Check the latest studies of Sitagliptin.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

On Aug, 10, 2026

67 people who take Sitagliptin and Valacyclovir together, and have interactions are studied.

Sitagliptin and Valacyclovir drug interactions.

What are the common drug interactions of Sitagliptin and Valacyclovir, by gender? *:

female:

Oedema peripheral (superficial swelling)
Asthenia (weakness)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)

male:

Myelitis (infection or the inflammation of white matter or gray matter of spinal cord which is a part of central nervous system)
Pneumonia
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Aplasia (defective development or congenital absence of an organ or tissue)
Drug ineffective
Nephropathy toxic (damage to kidney due to toxins)
Respiratory failure (inadequate gas exchange by the respiratory system)
Right ventricular failure (right half of the heart fails to work)

What are the common drug interactions of Sitagliptin and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Mixed liver injury

50-59:

Myelitis (infection or the inflammation of white matter or gray matter of spinal cord which is a part of central nervous system)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Drug ineffective
Humerus fracture (injury to the upper arm bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Scapula fracture (a fracture of the scapula, the shoulder blade)
Toxic skin eruption (skin breakdown due to toxic substance)
Ulna fracture (fracture inside bone)

60+:

Pneumonia
Oedema peripheral (superficial swelling)
Anaemia (lack of blood)
Blood creatinine increased
C-reactive protein decreased
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

Type 2 Diabetes: 19 people, 28.36%
Multiple Myeloma (cancer of the plasma cells): 19 people, 28.36%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 15 people, 22.39%
Folate Deficiency (lack of folic acid): 11 people, 16.42%
High Blood Pressure: 10 people, 14.93%
Diabetes: 10 people, 14.93%
Type 1 Diabetes: 9 people, 13.43%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 9 people, 13.43%
Device Related Infection: 8 people, 11.94%
Herpes Zoster: 7 people, 10.45%

* Approximation only. Some reports may have incomplete information.

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