Sodium bicarbonate and Enbrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sodium bicarbonate (sodium bicarbonate) and Enbrel (etanercept). Common drug interactions include musculoskeletal pain among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Sodium bicarbonate and Enbrel. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

On Jul, 17, 2026

71 people who take Sodium bicarbonate and Enbrel together, and have interactions are studied.

Sodium bicarbonate and Enbrel drug interactions.

What are the common drug interactions of Sodium Bicarbonate and Enbrel, by gender? *:

female:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain in extremity
Peripheral swelling
Pneumonia
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gastrointestinal toxicity (damage to digestive tract by any substance)
Hepatotoxicity (chemical-driven liver damage)

male:

Renal failure (kidney dysfunction)
Back pain
Anaemia (lack of blood)
Nephrolithiasis (calculi in the kidneys)
Pain
Pneumonia
Diarrhoea
Abdominal pain upper
Cellulitis (infection under the skin)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)

What are the common drug interactions of Sodium Bicarbonate and Enbrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Splenic infarction (tissue damage of spleen)

20-29:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Arthralgia (joint pain)
Cardiac failure acute
Decreased appetite
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Gastric ulcer (stomach ulcer)
Glaucoma (increased fluid pressure in the eye with vision loss)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nasal ulcer (ulcer of nose)
Pharyngitis (inflammation of the pharynx, causing a sore throat)

30-39:

n/a

40-49:

Thrombocytopenia (decrease of platelets in blood)
Pain
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hydronephrosis (water inside the kidney)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

50-59:

Arthralgia (joint pain)
Back pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Cough
Drug effect decreased
Drug ineffective
Haematocrit decreased
Headache (pain in head)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)

60+:

Renal failure (kidney dysfunction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dysuria (painful or difficult urination)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injection site oedema
Injection site pain

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 9.86%
Hyperkalemia (damage to or disease of the kidney): 5 people, 7.04%
Pain: 4 people, 5.63%
Osteoporosis (bones weak and more likely to break): 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

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