Sodium bicarbonate and Opdivo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sodium bicarbonate (sodium bicarbonate) and Opdivo (nivolumab). Common drug interactions include death among females and malignant neoplasm progression among males.

The phase IV clinical study analyzes what interactions people have when they take Sodium bicarbonate and Opdivo. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

73 people who take Sodium bicarbonate and Opdivo together, and have interactions are studied.

Sodium bicarbonate and Opdivo drug interactions.

What are the common drug interactions of Sodium Bicarbonate and Opdivo, by gender? *:

female:

Death
Adverse event
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Genital infection fungal
Malignant neoplasm progression (cancer tumour came back)
Oral fungal infection
Reiter's syndrome (a type of reactive arthritis, it happens as a reaction to a bacterial infection)
Stomatitis (inflammation of mucous membrane of mouth)
Abdominal pain
Cough

male:

Malignant neoplasm progression (cancer tumour came back)
Pruritus (severe itching of the skin)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Metastases to central nervous system (cancer spreads to central nervous system)
Blood pressure increased
Dry skin
Rash pruritic (redness with itching)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Death
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

What are the common drug interactions of Sodium Bicarbonate and Opdivo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lymphatic fistula (a leakage of lymphatic fluid from lymphatic vessel)
Malignant neoplasm progression (cancer tumour came back)

50-59:

Malignant neoplasm progression (cancer tumour came back)
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)
Death
Anxiety disorder
Cholangitis (infection of the bile duct)
Electrolyte imbalance
Neuropathy peripheral (surface nerve damage)
Thyroid disorder (thyroid diseases)

60+:

Malignant neoplasm progression (cancer tumour came back)
Diarrhoea
Metastases to central nervous system (cancer spreads to central nervous system)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Pericardial effusion malignant (cancerous fluid around the heart)
Blood pressure increased
Dry skin
Pruritus (severe itching of the skin)
Pyrexia (fever)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 34 people, 46.58%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 9 people, 12.33%
Type 2 Diabetes: 8 people, 10.96%
Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 7 people, 9.59%
Pain: 5 people, 6.85%
Metastases To Lung (cancer spreads to lung): 5 people, 6.85%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 6.85%
High Blood Pressure: 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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