Sodium fluoride and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sodium fluoride (fluoride) and Tylenol (acetaminophen). Common drug interactions include type 2 diabetes mellitus among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Sodium fluoride and Tylenol. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Sodium fluoride?

Sodium fluoride has active ingredients of fluoride. It is often used in dental cavities. eHealthMe is studying from 1,216 Sodium fluoride users. Check the latest studies of Sodium fluoride.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

On Aug, 09, 2026

70 people who take Sodium fluoride and Tylenol together, and have interactions are studied.

Sodium fluoride and Tylenol drug interactions.

What are the common drug interactions of Sodium Fluoride and Tylenol, by gender? *:

female:

Type 2 diabetes mellitus
Wound
Nausea (feeling of having an urge to vomit)
Upper respiratory tract infection
Asthma
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood cholesterol increased
Discomfort
General physical health deterioration (weak health status)
Hand deformity

male:

Anxiety
Sedation
Dysstasia (difficulty in standing)
Ecthyma (an ulcerative pyoderma of the skin, caused by group a beta haemolytic streptococci)
Emotional distress
Gait disturbance
General physical health deterioration (weak health status)
Hospitalisation
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mobility decreased (ability to move is reduced)

What are the common drug interactions of Sodium Fluoride and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Diarrhoea
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Somnolence (a state of near-sleep, a strong desire for sleep)
Incoherent (talking in a confused and unclear way)
Upper respiratory tract infection
Aerophagia (excessive air swallowing)
Anaemia (lack of blood)
Anticonvulsant drug level increased
Candida pneumonia (infection of lung by candida)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)

10-19:

Diarrhoea
Weight decreased
Constipation
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)
Retching (strong involuntary effort to vomit)
Vomiting
Electrocardiogram qt prolonged

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)

30-39:

Abdominal discomfort
Infection
Injection site erythema (redness at injection site)
Injection site pain
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

40-49:

Alopecia (absence of hair from areas of the body)
Decreased appetite
Drug ineffective
Drug intolerance (drug sensitivity)
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Fibromyalgia (a long-term condition which causes pain all over the body)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Infusion related reaction
Maternal exposure during pregnancy (use of substance during pregnancy)
Oedema (fluid collection in tissue)

50-59:

Hip arthroplasty
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pericarditis (inflammation of the pericardium)
Pneumonia
Swelling
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Type 2 diabetes mellitus
Wound

60+:

Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Fracture nonunion (permanent failure of healing following a broken bone)
Impaired healing
Metastatic neoplasm (spreadable cancer tumour)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pathological fracture (broken bone caused by disease)
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 15.71%
Cystic Fibrosis (disease of the secretary glands): 8 people, 11.43%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 11.43%
Constipation: 8 people, 11.43%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 10.00%
Fever: 7 people, 10.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 8.57%
Multiple Myeloma (cancer of the plasma cells): 6 people, 8.57%
Hypersensitivity: 6 people, 8.57%
Headache (pain in head): 6 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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