Sofosbuvir and Efavirenz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sofosbuvir (sofosbuvir) and Efavirenz (efavirenz). Common drug interactions include insomnia among females and hepatitis c among males.

The phase IV clinical study analyzes what interactions people have when they take Sofosbuvir and Efavirenz. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

What is Efavirenz?

Efavirenz has active ingredients of efavirenz. It is often used in hiv infection. eHealthMe is studying from 15,501 Efavirenz users. Check the latest studies of Efavirenz.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

45 people who take Sofosbuvir and Efavirenz together, and have interactions are studied.

Sofosbuvir and Efavirenz drug interactions.

What are the common drug interactions of Sofosbuvir and Efavirenz, by gender? *:

female:

Insomnia (sleeplessness)
Neuropathy peripheral (surface nerve damage)
Pathogen resistance
Skin ulcer
Asthenia (weakness)
Dizziness
Fall
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hypokalaemia (low potassium)
Immunodeficiency

male:

Hepatitis c
Hepatocellular carcinoma (liver cancer)
Chronic hepatic failure (long lasting liver failure)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypersensitivity
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Venous injury

What are the common drug interactions of Sofosbuvir and Efavirenz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hepatitis c
Hypersensitivity

50-59:

Hepatocellular carcinoma (liver cancer)
Immune system disorder
Immunodeficiency
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Proteinuria (presence of protein in the urine)
Pyuria (a condition of urine containing pus)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Insomnia (sleeplessness)
Neuropathy peripheral (surface nerve damage)

60+:

n/a

What are the existing conditions these people have? *

Hepatitis C: 30 people, 66.67%
Hiv Test Positive: 20 people, 44.44%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 5 people, 11.11%
Dyslipidaemia (abnormal amount of lipids): 5 people, 11.11%
Stress And Anxiety: 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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