Soliris and Ambisome drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Ambisome (amphotericin b). Common drug interactions include renal impairment among females and renal impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Ambisome. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Ambisome?

Ambisome has active ingredients of amphotericin b. eHealthMe is studying from 7,934 Ambisome users. Check the latest studies of Ambisome.

On Jul, 13, 2026

14 people who take Soliris and Ambisome together, and have interactions are studied.

What are the common drug interactions of Soliris and Ambisome, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Drug ineffective
Anaemia (lack of blood)
Cytomegalovirus infection
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Neuroblastoma (a cancer that forms in your nerve tissue)
Neutropenia (an abnormally low number of neutrophils)
Pericardial effusion (fluid around the heart)
Pulmonary haemorrhage (acute bleeding from the lung)
Renal failure (kidney dysfunction)

male:

Renal impairment (severely reduced kidney function)
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)
Pneumonia
Pulmonary alveolar haemorrhage (acute bleeding)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemodynamic instability (disturbances in the blood movement in our body)
Hypotension (abnormally low blood pressure)
Idiopathic pneumonia syndrome (pneumonia-like symptoms)

What are the common drug interactions of Soliris and Ambisome, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anaemia (lack of blood)
Cytomegalovirus infection
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Neuroblastoma (a cancer that forms in your nerve tissue)
Neutropenia (an abnormally low number of neutrophils)
Pulmonary haemorrhage (acute bleeding from the lung)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

10-19:

Renal impairment (severely reduced kidney function)
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemodynamic instability (disturbances in the blood movement in our body)
Hypotension (abnormally low blood pressure)
Idiopathic pneumonia syndrome (pneumonia-like symptoms)
Lung disorder (lung disease)
Drug ineffective
Pericardial effusion (fluid around the heart)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)

20-29:

n/a

30-39:

n/a

40-49:

Pneumonia
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

50-59:

Cardiac arrest
Lung disorder (lung disease)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

60+:

Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Drug ineffective
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)

What are the existing conditions these people have? *

Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 8 people, 57.14%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 5 people, 35.71%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 28.57%
Dyspnea (difficult or laboured breathing): 3 people, 21.43%
Fungal Infection: 3 people, 21.43%
Gastric Ulcer (stomach ulcer): 3 people, 21.43%
Immunodeficiency Disorders: 3 people, 21.43%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 3 people, 21.43%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 14.29%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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