Soliris and Cytoxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Cytoxan (cyclophosphamide). Common drug interactions include hypocalcaemia among females and bk virus infection among males.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Cytoxan. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

On Jul, 04, 2026

21 people who take Soliris and Cytoxan together, and have interactions are studied.

What are the common drug interactions of Soliris and Cytoxan, by gender? *:

female:

Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypoxia (low oxygen in tissues)
Impaired healing
Influenza like illness
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Leukocytosis (increased white blood cells)
Malaise (a feeling of general discomfort or uneasiness)

male:

Bk virus infection
Leukopenia (less number of white blood cells in blood)
Chemotherapy
Coagulopathy (blood's ability to clot is impaired)
Crepitations (noises are produced by the rubbing of parts one against the other)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed level of consciousness
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Fluid overload (too much fluid in the blood)
Fungaemia (fungi circulate in the blood)

What are the common drug interactions of Soliris and Cytoxan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Death
Iga nephropathy (kidney disease- condition prevents the kidneys from filtering waste)
Pyrexia (fever)
Renal osteodystrophy (a bone disease occurs when the kidneys fail to maintain the proper levels of calcium and phosphorus in the blood)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

10-19:

n/a

20-29:

Haematocrit decreased
Haemoglobin decreased
Platelet count decreased

30-39:

n/a

40-49:

Hyperlipidaemia (presence of excess lipids in the blood)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypersensitivity
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypoxia (low oxygen in tissues)
Impaired healing
Influenza like illness
Infusion related reaction

50-59:

Depression
Fatigue (feeling of tiredness)
Gallbladder polyp (growths or lesions resembling growths (polypoid lesions) in the wall of the gallbladder)
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Injection site reaction
Injection site swelling
Injection site warmth
Weight increased

60+:

Aphasia (damage to the parts of the brain that control language)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed level of consciousness
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Fungaemia (fungi circulate in the blood)
Fungal infection
Haemoglobin decreased

What are the existing conditions these people have? *

Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 8 people, 38.10%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 6 people, 28.57%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 4 people, 19.05%
High Blood Pressure: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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