Soliris and Vancomycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Vancomycin (vancomycin). Common drug interactions include blood pressure decreased among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Vancomycin. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Vancomycin?

Vancomycin has active ingredients of vancomycin. eHealthMe is studying from 17,165 Vancomycin users. Check the latest studies of Vancomycin.

On Jul, 15, 2026

23 people who take Soliris and Vancomycin together, and have interactions are studied.

Soliris and Vancomycin drug interactions.

What are the common drug interactions of Soliris and Vancomycin, by gender? *:

female:

Blood pressure decreased
Death
Diarrhoea
Haematoma (collection of blood outside the blood vessels)
Pulmonary alveolar haemorrhage (acute bleeding)
Abdominal pain
Adenovirus infection
Anaemia (lack of blood)
Anuria (failure of the kidneys to produce urine)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)

male:

Acute respiratory failure
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatic failure (liver failure)
Renal impairment (severely reduced kidney function)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Ankle fracture
Arteriovenous fistula
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Death

What are the common drug interactions of Soliris and Vancomycin, by age (0-1 to 60+)? *:

0-1:

Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Diarrhoea haemorrhagic (bloody diarrhoea)
Hepatic failure (liver failure)
Renal impairment (severely reduced kidney function)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Abdominal pain
Anaemia (lack of blood)
Anuria (failure of the kidneys to produce urine)
Biliary cirrhosis (biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver)
Biliary tract disorder

2-9:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Death
Diarrhoea
Hepatic enzyme increased
Nausea (feeling of having an urge to vomit)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Respiratory distress (difficulty in breathing)
Venoocclusive liver disease (small veins in the liver are obstructed)
Vomiting
Adenovirus infection

10-19:

Chronic granulomatous disease (immune system cells are unable to kill some types of bacteria and fungi)
Diffuse alveolar damage (common manifestation of drug-induced lung injury)
Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
Pneumomediastinum (air is present in the mediastinum)
Pulmonary alveolar haemorrhage (acute bleeding)
Pulmonary infarction (death of a small area of lung)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

20-29:

Arteriovenous fistula

30-39:

White blood cell count decreased

40-49:

n/a

50-59:

n/a

60+:

Cardiac valve vegetation (heart valve abnormal growth)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Myasthenia gravis crisis (a paralysis of the respiratory muscles occurs)
Pneumonia
Sinusitis (inflammation of sinus)
Spinal cord compression

What are the existing conditions these people have? *

Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 6 people, 26.09%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 3 people, 13.04%
Immunodeficiency Disorders: 3 people, 13.04%
High Blood Pressure: 2 people, 8.70%
Cytomegalovirus Infection: 2 people, 8.70%
Cellulitis (infection under the skin): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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