Soliris and Zemplar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soliris (eculizumab) and Zemplar (paricalcitol). Common drug interactions include bacillus infection among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Soliris and Zemplar. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

What is Zemplar?

Zemplar has active ingredients of paricalcitol. It is often used in kidney disease. eHealthMe is studying from 15,494 Zemplar users. Check the latest studies of Zemplar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

19 people who take Soliris and Zemplar together, and have interactions are studied.

What are the common drug interactions of Soliris and Zemplar, by gender? *:

female:

Bacillus infection
Device related infection
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Dyspepsia (indigestion)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Vomiting
Asthma
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)

male:

Abdominal discomfort
Confusional state
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Rhinorrhoea (watery mucus discharge from the nose)
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred
Bacillus infection
Dizziness
Excoriation (to tear or wear off the skin of)

What are the common drug interactions of Soliris and Zemplar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Bacillus infection

10-19:

Nausea (feeling of having an urge to vomit)
Dyspepsia (indigestion)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Anaemia (lack of blood)
Arteriovenous fistula thrombosis (formation of a blood clot inside a blood vessel-av fistula)
Arthralgia (joint pain)
Arthropathy
Asthenia (weakness)

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Bone pain
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Headache (pain in head)
Myalgia (muscle pain)
Transfusion reaction (a serious problem that occurs after a patient receives a transfusion of blood)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fluid retention (an abnormal accumulation of fluid in the blood)

40-49:

Drug level decreased
Drug level increased
Upper respiratory tract infection

50-59:

n/a

60+:

Bacillus infection
Device related infection
Asthma
Malaise (a feeling of general discomfort or uneasiness)
Renal transplant
Nasopharyngitis (inflammation of the nasopharynx)
Rhinorrhoea (watery mucus discharge from the nose)

What are the existing conditions these people have? *

Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 17 people, 89.47%
High Blood Pressure: 9 people, 47.37%
Diabetes: 3 people, 15.79%
Itching: 3 people, 15.79%
Electrolyte Imbalance: 3 people, 15.79%
Hyperkalemia (damage to or disease of the kidney): 2 people, 10.53%
Chronic Kidney Disease: 2 people, 10.53%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 10.53%
Cytomegalovirus Infection: 2 people, 10.53%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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