Solu-cortef and Imodium a-d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solu-cortef (hydrocortisone sodium succinate) and Imodium a-d (loperamide hydrochloride). Common drug interactions include headache among females and white blood cell count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Solu-cortef and Imodium a-d. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

On Jul, 26, 2026

11 people who take Solu-cortef and Imodium a-d together, and have interactions are studied.

Solu-cortef and Imodium a-d drug interactions.

What are the common drug interactions of Solu-Cortef and Imodium A-D, by gender? *:

female:

Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Mouth ulceration (mouth ulcers)
Mucosal inflammation (infection of mucous membrane)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Cataract (clouding of the lens inside the eye)

male:

White blood cell count decreased
Anxiety
Hypertension (high blood pressure)
Infusion related reaction
Large intestine perforation (hole in large intestine)
Pneumonia
Retroperitoneal abscess (a collection of pus between the peritoneum and the posterior abdominal wall. retroperitoneal. behind the peritoneum)
Sinusitis (inflammation of sinus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urine output decreased

What are the common drug interactions of Solu-Cortef and Imodium A-D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

White blood cell count decreased
Asthenia (weakness)
Enterocolonic fistula
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hospitalisation
Impaired gastric emptying
Large intestine perforation (hole in large intestine)
Retroperitoneal abscess (a collection of pus between the peritoneum and the posterior abdominal wall. retroperitoneal. behind the peritoneum)
Urine output decreased

60+:

Asthenia (weakness)
Epistaxis (bleed from the nose)
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Infusion related reaction
Pneumonia
Sinusitis (inflammation of sinus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Mouth ulceration (mouth ulcers)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 4 people, 36.36%
Immunodeficiency Common Variable: 2 people, 18.18%
Weakness: 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Central Nervous System Infection (infection of brain or spinal cord): 1 person, 9.09%
Constipation: 1 person, 9.09%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 9.09%
Electrolyte Imbalance: 1 person, 9.09%
Febrile Neutropenia (fever with reduced white blood cells): 1 person, 9.09%
Fever: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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