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Solu-cortef and Pentam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solu-cortef (hydrocortisone sodium succinate) and Pentam (pentamidine isethionate). Common drug interactions include bone pain among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Solu-cortef and Pentam. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

What is Pentam?

Pentam has active ingredients of pentamidine isethionate. eHealthMe is studying from 5,686 Pentam users. Check the latest studies of Pentam.

On Jul, 11, 2026

20 people who take Solu-cortef and Pentam together, and have interactions are studied.

Solu-cortef and Pentam drug interactions.

What are the common drug interactions of Solu-Cortef and Pentam, by gender? *:

female:

  1. Bone pain
  2. Bradycardia (abnormally slow heart action)
  3. Breath sounds
  4. Burning sensation
  5. Cardiac murmur (an heart sound in valve abnormality)
  6. Chest pain
  7. Chills (felling of cold)
  8. Claustrophobia (fear of having no escape and being closed in small spaces)
  9. Clostridium colitis (inflammation of colon by clostridium difficile bacteria infection)
  10. Colitis ischaemic (due to infection of intestine impaired blood supply to colon)

male:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Blood albumin decreased
  4. Blood calcium decreased
  5. Blood chloride increased
  6. Blood creatinine decreased
  7. Blood fibrinogen decreased
  8. Blood glucose increased
  9. Blood lactate dehydrogenase increased
  10. Blood magnesium increased

What are the common drug interactions of Solu-Cortef and Pentam, by age (0-1 to 60+)? *:

0-1:

  1. Abdominal infection
  2. Activated partial thromboplastin time prolonged
  3. Alanine aminotransferase increased
  4. Ammonia decreased
  5. Anaemia (lack of blood)
  6. Anion gap increased
  7. Aspartate aminotransferase increased
  8. Blast cell count increased
  9. Blood albumin decreased
  10. Blood calcium decreased

2-9:

  1. Tooth abscess (pus formation in tooth)
  2. Lactic acidosis (low ph in body tissues)
  3. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  4. Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
  5. Diarrhoea
  6. Diarrhoea haemorrhagic (bloody diarrhoea)
  7. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  8. Haematoma (collection of blood outside the blood vessels)
  9. Pleural effusion (water on the lungs)
  10. Pyrexia (fever)

10-19:

  1. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  2. Alanine aminotransferase increased
  3. Arthralgia (joint pain)
  4. Arthropathy
  5. Aspartate aminotransferase increased
  6. Bone infarction (ischemic death of the cellular elements of the bone and marrow)
  7. Bone pain
  8. Decreased appetite
  9. Gait disturbance
  10. Headache (pain in head)

20-29:

n/a

30-39:

  1. Febrile neutropenia (fever with reduced white blood cells)
  2. Abdominal distension
  3. Abscess (pus)
  4. Anaemia (lack of blood)
  5. Anxiety
  6. Arthralgia (joint pain)
  7. Atelectasis (partial or complete collapse of the lung)
  8. Back pain
  9. Bacterial infection
  10. Bacteriuria (presence of bacteria in urine)

40-49:

n/a

50-59:

n/a

60+:

  1. Asthma
  2. Cardiac failure
  3. Pleural effusion (water on the lungs)
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  6. Rash
  7. Skin disorder (skin disease)
  8. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  9. Troponin increased

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 8 people, 40.00%
  2. Insomnia (sleeplessness): 7 people, 35.00%
  3. Bone Pain: 6 people, 30.00%
  4. Proctalgia (pain in the rectum): 5 people, 25.00%
  5. Thrombocytopenia (decrease of platelets in blood): 5 people, 25.00%
  6. Allergic Transfusion Reaction: 5 people, 25.00%
  7. Oedema (fluid collection in tissue): 5 people, 25.00%
  8. Stomatitis (inflammation of mucous membrane of mouth): 5 people, 25.00%
  9. Pain: 4 people, 20.00%
  10. Infection: 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

Do you take Solu-cortef and Pentam?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Solu-cortef and Pentam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Solu-cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pentam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Solu-cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pentam and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone sodium succinate and pentamidine isethionate (the active ingredients of Solu-cortef and Pentam, respectively), and Solu-cortef and Pentam (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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