Solu-cortef and Ursodeoxycholic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Solu-cortef (hydrocortisone sodium succinate) and Ursodeoxycholic acid (ursodiol). Common drug interactions include erythema among females and adrenocortical insufficiency acute among males.

The phase IV clinical study analyzes what interactions people have when they take Solu-cortef and Ursodeoxycholic acid. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

What is Ursodeoxycholic acid?

Ursodeoxycholic acid has active ingredients of ursodiol. It is often used in biliary cirrhosis primary. eHealthMe is studying from 7,528 Ursodeoxycholic acid users. Check the latest studies of Ursodeoxycholic acid.

On Jul, 14, 2026

35 people who take Solu-cortef and Ursodeoxycholic acid together, and have interactions are studied.

Solu-cortef and Ursodeoxycholic acid drug interactions.

What are the common drug interactions of Solu-Cortef and Ursodeoxycholic Acid, by gender? *:

female:

Erythema (redness of the skin)
Faeces pale
Jaundice cholestatic
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Rash
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrointestinal perforation (hole in the digestive tract)
Hepatic steatosis (fatty liver disease)

male:

Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Pyrexia (fever)
Erythema multiforme (a type of hypersensitivity reaction)
Gastrointestinal anastomotic leak (breakdown at the site of a post-surgical closure of a stomach and intestine)
Hepatic vein stenosis
Influenza
Liver transplant rejection (failure of liver transplant)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Post procedural bile leak
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)

What are the common drug interactions of Solu-Cortef and Ursodeoxycholic Acid, by age (0-1 to 60+)? *:

0-1:

Eosinophil count increased
Faeces pale
Jaundice cholestatic
Liver disorder (liver diseases)

2-9:

n/a

10-19:

n/a

20-29:

Influenza
Liver transplant rejection (failure of liver transplant)
Post procedural bile leak
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Suture rupture
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrointestinal perforation (hole in the digestive tract)

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood creatine phosphokinase increased
Gamma-glutamyltransferase increased
General physical health deterioration (weak health status)
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
Hepatic vein occlusion (blockage of the hepatic vein)
Lymphadenopathy (disease or enlargement of lymph nodes)
Platelet count decreased

40-49:

Septic shock (shock due to blood infection)

50-59:

Pyrexia (fever)
Blood creatine phosphokinase increased
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Malaise (a feeling of general discomfort or uneasiness)

60+:

Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Death
Cardiogenic shock (inadequate circulation of blood)
Chronic kidney disease
Infection
Pneumonia
Pulmonary alveolar haemorrhage (acute bleeding)
Rash
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased)
Alanine aminotransferase increased

What are the existing conditions these people have? *

Diabetes: 10 people, 28.57%
Vasculitis (inflammation of a blood vessel or blood vessels): 7 people, 20.00%
Idiopathic Thrombocytopenic Purpura (Itp) (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 7 people, 20.00%
Hepatic Steatosis (fatty liver disease): 7 people, 20.00%
High Blood Pressure: 7 people, 20.00%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 7 people, 20.00%
Renal Cell Carcinoma (a kidney cancer): 6 people, 17.14%
Fever: 6 people, 17.14%
Pneumonia: 4 people, 11.43%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.43%

* Approximation only. Some reports may have incomplete information.

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