Soma and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soma (carisoprodol) and Arava (leflunomide). Common drug interactions include dizziness among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Soma and Arava. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Jul, 08, 2026

91 people who take Soma and Arava together, and have interactions are studied.

What are the common drug interactions of Soma and Arava, by gender? *:

female:

Dizziness
Neuropathy peripheral (surface nerve damage)
Somnolence (a state of near-sleep, a strong desire for sleep)
Androgen deficiency
Bruxism (habitual grinding of the teeth, typically during sleep)
Confusional state
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Eye irritation
Gait disturbance
Tibia fracture (fracture of lower leg bone)

male:

Gait disturbance
Insomnia (sleeplessness)
Spondyloarthropathy (any joint disease of the vertebral column)
Fall
Synovitis (inflammation of the synovial membrane)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Drug ineffective
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Abdominal pain upper
Anaemia (lack of blood)

What are the common drug interactions of Soma and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Blood pressure decreased
Heart rate decreased
Obesity (having too much body fat)
Oxygen saturation immeasurable
Pallor
Pneumonia
Pulmonary congestion (congestion in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

Anaemia (lack of blood)
Dizziness (excl vertigo)
Dysphagia (a condition in which swallowing is difficult or painful)
Ear pain
Headache (pain in head)
Injection site reaction
Insomnia (sleeplessness)
Jugular vein thrombosis (clot in jugular vein)
Lethargy (tiredness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

40-49:

Blindness
Depression
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Injection site pain
Optic neuritis (optic nerve inflammation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Open fracture
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Postoperative wound complication
Pyrexia (fever)
Red blood cell count decreased
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)
Sleep disorder
Vasculitis (inflammation of a blood vessel or blood vessels)
Vision blurred
Abasia (inability to walk)

60+:

Gait disturbance
Insomnia (sleeplessness)
Spondyloarthropathy (any joint disease of the vertebral column)
Fall
Synovitis (inflammation of the synovial membrane)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Drug ineffective
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Pain in extremity
Arthralgia (joint pain)

What are the existing conditions these people have? *

Pain: 28 people, 30.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 14 people, 15.38%
High Blood Pressure: 10 people, 10.99%
Spondyloarthropathy (any joint disease of the vertebral column): 8 people, 8.79%
Sleep Disorder: 8 people, 8.79%
Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 7.69%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 6.59%
Osteoporosis (bones weak and more likely to break): 6 people, 6.59%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 6.59%
High Blood Cholesterol: 6 people, 6.59%

* Approximation only. Some reports may have incomplete information.

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