Soma and Estraderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soma (carisoprodol) and Estraderm (estradiol). Common drug interactions include spinal osteoarthritis among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Soma and Estraderm. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

What is Estraderm?

Estraderm has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,441 Estraderm users. Check the latest studies of Estraderm.

On Jul, 13, 2026

31 people who take Soma and Estraderm together, and have interactions are studied.

What are the common drug interactions of Soma and Estraderm, by gender? *:

female:

Spinal osteoarthritis (joint cartilage loss in spine)
Osteopenia (a condition where bone mineral density is lower than normal)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Anxiety
Pain in extremity
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Chest pain
Cough
Diarrhoea
Gait disturbance

male:

Abdominal pain upper
Abscess (pus)
Bunion (a painful swelling on the first joint of the big toe)
Cancer pain
Cardiomegaly (increased size of heart than normal)
Cerebrovascular disorder (disease of brain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Soma and Estraderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Eye swelling
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nausea (feeling of having an urge to vomit)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Alopecia (absence of hair from areas of the body)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Bone pain

50-59:

Sinusitis (inflammation of sinus)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tendon rupture (tear of tendon)
Thoracic vertebral fracture
Tibia fracture (fracture of lower leg bone)
Tooth disorder (tooth disease)
Tooth fracture
Toothache (tooth pain)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Upper-airway cough syndrome

60+:

Nausea (feeling of having an urge to vomit)
Decreased appetite
Asthma
Chest pain
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

What are the existing conditions these people have? *

Bone Density Abnormal: 8 people, 25.81%
Menopause (end of monthly cycles in women): 7 people, 22.58%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 22.58%
Osteoporosis (bones weak and more likely to break): 5 people, 16.13%
Migraine (headache): 3 people, 9.68%
Gastrointestinal Neoplasm (cancer tumour of digestive tract): 3 people, 9.68%
Constipation: 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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