Soma and Vyvanse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Soma (carisoprodol) and Vyvanse (lisdexamfetamine dimesylate). Common drug interactions include surgery among females and chronic lymphocytic leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Soma and Vyvanse. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,870 Vyvanse users. Check the latest studies of Vyvanse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

59 people who take Soma and Vyvanse together, and have interactions are studied.

What are the common drug interactions of Soma and Vyvanse, by gender? *:

female:

Surgery
Tremor (trembling or shaking movements in one or more parts of your body)
Visual impairment
Abnormal loss of weight
Blood glucose increased
Glaucoma (increased fluid pressure in the eye with vision loss)
Menopause (end of monthly cycles in women)
Seasonal allergy (allergic condition due to certain season)
Sleep disorder
Abdominal pain

male:

Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Death
Weight decreased
Abdominal distension
Abdominal pain upper
Alcohol withdrawal syndrome
Alcoholic pancreatitis
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation

What are the common drug interactions of Soma and Vyvanse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bedridden
Memory impairment
Alcohol withdrawal syndrome
Alcoholic pancreatitis
Antisocial behaviour
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Pancreatitis acute (sudden inflammation of pancreas)
Poisoning
Sedation
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Corneal degeneration (abnormal deposition of substances in the transparent front part of the eye)
Diarrhoea
Ear infection
Glaucoma (increased fluid pressure in the eye with vision loss)
Injection site erythema (redness at injection site)
Injection site reaction
Injection site swelling
Injection site warmth
Pneumonia
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

40-49:

Lip swelling
Lymphadenopathy (disease or enlargement of lymph nodes)
Mood altered (changes in mood)
Muscle atrophy (a decrease in the mass of the muscle)
Pyrexia (fever)
Tinnitus (a ringing in the ears)
Urinary tract infection
Weight decreased
Migraine (headache)
Decreased appetite

50-59:

Alveolar osteitis (complication of wound healing following extraction of a tooth)
Anaemia (lack of blood)
Bruxism (habitual grinding of the teeth, typically during sleep)
Incision site pain
Incisional drainage
Jaw disorder (jaw disease)
Pain in jaw
Spinal cord compression
Synovial cyst (cyst of joint filled with synovial fluid)
Tooth disorder (tooth disease)

60+:

Death
Nausea (feeling of having an urge to vomit)
Neurological symptom (symptoms of nervous system disease)
Pruritus (severe itching of the skin)
Rash
Tenosynovitis (inflammation of the fluid-filled sheath (called the synovium) that surrounds a tendon)
Throat irritation
Vision blurred
Visual field defect
White blood cell count increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 44.07%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 23.73%
Stress And Anxiety: 6 people, 10.17%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 10.17%
Pain: 6 people, 10.17%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.17%
Drowsiness: 6 people, 10.17%
Depression: 6 people, 10.17%
Thyroid Diseases: 5 people, 8.47%
Back Pain: 5 people, 8.47%

* Approximation only. Some reports may have incomplete information.

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