Sonata and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Atarax (hydroxyzine hydrochloride). Common drug interactions include hypertension among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Atarax. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

On Jul, 30, 2026

33 people who take Sonata and Atarax together, and have interactions are studied.

What are the common drug interactions of Sonata and Atarax, by gender? *:

female:

Hypertension (high blood pressure)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypotension (abnormally low blood pressure)
Intentional self-injury
Low density lipoprotein
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)

male:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Sweating increased (excess sweating)
Therapeutic response unexpected
Vision blurred
Abdominal pain
Affect lability (emotional incontinence)
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)

What are the common drug interactions of Sonata and Atarax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aphonia (inability to produce voice)
Drug ineffective
Dry skin
Dyspnoea (difficult or laboured respiration)
Exfoliative rash (scaly red generalized skin rash)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Influenza
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Completed suicide (act of taking one's own life)
Depression
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Neuralgia (pain in one or more nerves)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Weight decreased
Coma (state of unconsciousness lasting more than six hours)

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Non-cardiac chest pain
Abdominal pain
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arthropathy
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus

60+:

Dehydration (dryness resulting from the removal of water)
Acute respiratory failure
Lung disorder (lung disease)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multi-organ disorder (multiple organ disease)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Paranasal sinus hypersecretion
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Depression: 8 people, 24.24%
Pain: 7 people, 21.21%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 15.15%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 12.12%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 9.09%
Sleep Disorder: 3 people, 9.09%
Intervertebral Disc Degeneration (spinal disc degeneration): 3 people, 9.09%
Dissociative Disorder: 3 people, 9.09%
Hypogonadism Female (female ovaries produce little or no sex hormones): 3 people, 9.09%
Nausea And Vomiting: 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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